Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment—An Update
Glioblastoma (GBM) is the most commonly diagnosed and most lethal primary malignant brain tumor in adults. Standard treatments are ineffective, and despite promising results obtained in early phases of experimental clinical trials, the prognosis of GBM remains unfavorable. Therefore, there is need f...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/7/1598 |
| _version_ | 1797407401359441920 |
|---|---|
| author | Agata M. Gawel Ravi Singh Waldemar Debinski |
| author_facet | Agata M. Gawel Ravi Singh Waldemar Debinski |
| author_sort | Agata M. Gawel |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most commonly diagnosed and most lethal primary malignant brain tumor in adults. Standard treatments are ineffective, and despite promising results obtained in early phases of experimental clinical trials, the prognosis of GBM remains unfavorable. Therefore, there is need for exploration and development of innovative methods that aim to establish new therapies or increase the effectiveness of existing therapies. One of the most exciting new strategies enabling combinatory treatment is the usage of nanocarriers loaded with chemotherapeutics and/or other anticancer compounds. Nanocarriers exhibit unique properties in antitumor therapy, as they allow highly efficient drug transport into cells and sustained intracellular accumulation of the delivered cargo. They can be infused into and are retained by GBM tumors, and potentially can bypass the blood–brain barrier. One of the most promising and extensively studied groups of nanostructured therapeutics are metal-based nanoparticles. These theranostic nanocarriers demonstrate relatively low toxicity, thus they might be applied for both diagnosis and therapy. In this article, we provide an update on metal-based nanostructured constructs in the treatment of GBM. We focus on the interaction of metal nanoparticles with various forms of electromagnetic radiation for use in photothermal, photodynamic, magnetic hyperthermia and ionizing radiation sensitization applications. |
| first_indexed | 2024-03-09T03:40:53Z |
| format | Article |
| id | doaj.art-dd95c00a52794ebc900689c4c01186bf |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T03:40:53Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-dd95c00a52794ebc900689c4c01186bf2023-12-03T14:41:52ZengMDPI AGBiomedicines2227-90592022-07-01107159810.3390/biomedicines10071598Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment—An UpdateAgata M. Gawel0Ravi Singh1Waldemar Debinski2Histology and Embryology Students’ Science Association, Department of Histology and Embryology, Faculty of Medicine, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, PolandDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USAGlioblastoma (GBM) is the most commonly diagnosed and most lethal primary malignant brain tumor in adults. Standard treatments are ineffective, and despite promising results obtained in early phases of experimental clinical trials, the prognosis of GBM remains unfavorable. Therefore, there is need for exploration and development of innovative methods that aim to establish new therapies or increase the effectiveness of existing therapies. One of the most exciting new strategies enabling combinatory treatment is the usage of nanocarriers loaded with chemotherapeutics and/or other anticancer compounds. Nanocarriers exhibit unique properties in antitumor therapy, as they allow highly efficient drug transport into cells and sustained intracellular accumulation of the delivered cargo. They can be infused into and are retained by GBM tumors, and potentially can bypass the blood–brain barrier. One of the most promising and extensively studied groups of nanostructured therapeutics are metal-based nanoparticles. These theranostic nanocarriers demonstrate relatively low toxicity, thus they might be applied for both diagnosis and therapy. In this article, we provide an update on metal-based nanostructured constructs in the treatment of GBM. We focus on the interaction of metal nanoparticles with various forms of electromagnetic radiation for use in photothermal, photodynamic, magnetic hyperthermia and ionizing radiation sensitization applications.https://www.mdpi.com/2227-9059/10/7/1598glioblastomametal-based nanocarrierscombinatory therapytheranostic nanocarriers |
| spellingShingle | Agata M. Gawel Ravi Singh Waldemar Debinski Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment—An Update Biomedicines glioblastoma metal-based nanocarriers combinatory therapy theranostic nanocarriers |
| title | Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment—An Update |
| title_full | Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment—An Update |
| title_fullStr | Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment—An Update |
| title_full_unstemmed | Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment—An Update |
| title_short | Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment—An Update |
| title_sort | metal based nanostructured therapeutic strategies for glioblastoma treatment an update |
| topic | glioblastoma metal-based nanocarriers combinatory therapy theranostic nanocarriers |
| url | https://www.mdpi.com/2227-9059/10/7/1598 |
| work_keys_str_mv | AT agatamgawel metalbasednanostructuredtherapeuticstrategiesforglioblastomatreatmentanupdate AT ravisingh metalbasednanostructuredtherapeuticstrategiesforglioblastomatreatmentanupdate AT waldemardebinski metalbasednanostructuredtherapeuticstrategiesforglioblastomatreatmentanupdate |