Efficacy of GMI, a fungal immunomodulatory protein, for head and neck cancer patients with chemotherapy-related oral mucositis
Abstract. Background:. Cancer patients usually suffer from intensive chemotherapy-related oral mucositis (OM), yet limited effective treatment can rapidly alleviate OM severity. Methods:. This prospective study examined the efficacy of Reishimmune-S containing one fungal immunomodulatory protein, GM...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2022-04-01
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| Series: | Medicine |
| Online Access: | http://journals.lww.com/10.1097/MD.0000000000029185 |
| _version_ | 1828795454874189824 |
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| author | Hsueh-Ju Lu, MD, PhD Che-Hsing Li, MD Yu-Ting Kang, PhD Chi-Mei Wu, MS Chih-Hsien Wu, PhD Jiunn-Liang Ko, PhD Ming-Fang Wu, MD, PhD Maya Saranathan. |
| author_facet | Hsueh-Ju Lu, MD, PhD Che-Hsing Li, MD Yu-Ting Kang, PhD Chi-Mei Wu, MS Chih-Hsien Wu, PhD Jiunn-Liang Ko, PhD Ming-Fang Wu, MD, PhD Maya Saranathan. |
| author_sort | Hsueh-Ju Lu, MD, PhD |
| collection | DOAJ |
| description | Abstract. Background:. Cancer patients usually suffer from intensive chemotherapy-related oral mucositis (OM), yet limited effective treatment can rapidly alleviate OM severity.
Methods:. This prospective study examined the efficacy of Reishimmune-S containing one fungal immunomodulatory protein, GMI on OM in patients with head and neck cancer. Patients with head and neck cancer and the diagnosis of chemotherapy-related OM were enrolled randomizedly to receive standard supportive care with/without Reishimmune-S 500 mg/day orally for consecutive 14 days. Due to intolerance to standard supportive care alone in the control arm, only the experimental arm with Reishimmune-S supplementation was analyzed in our trial. OM grading was evaluated as the primary outcome on day 1, 8, and 15. Secondary outcomes were absolute neutrophil counts and quality of life assessed by the EORTC-QLQ-H&N 35 questionnaire on day 1, 8, and 15.
Results:. Reishimmune-S supplement significantly reduced OM grading both at day 8 and 15. Trouble with social contact and weight loss conditions were also improved by Reishimmune-S. Reishimmune-S did not significantly affect absolute neutrophil counts during the 15-day follow-up.
Conclusion:. Reishimmune-S supplement potentially alleviates the severity of chemotherapy-mediated OM. |
| first_indexed | 2024-12-12T04:05:22Z |
| format | Article |
| id | doaj.art-dd98237dc68048d5902e68f14ea67579 |
| institution | Directory Open Access Journal |
| issn | 0025-7974 1536-5964 |
| language | English |
| last_indexed | 2024-12-12T04:05:22Z |
| publishDate | 2022-04-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Medicine |
| spelling | doaj.art-dd98237dc68048d5902e68f14ea675792022-12-22T00:38:48ZengWolters KluwerMedicine0025-79741536-59642022-04-0110116e2918510.1097/MD.0000000000029185202204220-00007Efficacy of GMI, a fungal immunomodulatory protein, for head and neck cancer patients with chemotherapy-related oral mucositisHsueh-Ju Lu, MD, PhDChe-Hsing Li, MDYu-Ting Kang, PhDChi-Mei Wu, MSChih-Hsien Wu, PhDJiunn-Liang Ko, PhDMing-Fang Wu, MD, PhDMaya Saranathan.Abstract. Background:. Cancer patients usually suffer from intensive chemotherapy-related oral mucositis (OM), yet limited effective treatment can rapidly alleviate OM severity. Methods:. This prospective study examined the efficacy of Reishimmune-S containing one fungal immunomodulatory protein, GMI on OM in patients with head and neck cancer. Patients with head and neck cancer and the diagnosis of chemotherapy-related OM were enrolled randomizedly to receive standard supportive care with/without Reishimmune-S 500 mg/day orally for consecutive 14 days. Due to intolerance to standard supportive care alone in the control arm, only the experimental arm with Reishimmune-S supplementation was analyzed in our trial. OM grading was evaluated as the primary outcome on day 1, 8, and 15. Secondary outcomes were absolute neutrophil counts and quality of life assessed by the EORTC-QLQ-H&N 35 questionnaire on day 1, 8, and 15. Results:. Reishimmune-S supplement significantly reduced OM grading both at day 8 and 15. Trouble with social contact and weight loss conditions were also improved by Reishimmune-S. Reishimmune-S did not significantly affect absolute neutrophil counts during the 15-day follow-up. Conclusion:. Reishimmune-S supplement potentially alleviates the severity of chemotherapy-mediated OM.http://journals.lww.com/10.1097/MD.0000000000029185 |
| spellingShingle | Hsueh-Ju Lu, MD, PhD Che-Hsing Li, MD Yu-Ting Kang, PhD Chi-Mei Wu, MS Chih-Hsien Wu, PhD Jiunn-Liang Ko, PhD Ming-Fang Wu, MD, PhD Maya Saranathan. Efficacy of GMI, a fungal immunomodulatory protein, for head and neck cancer patients with chemotherapy-related oral mucositis Medicine |
| title | Efficacy of GMI, a fungal immunomodulatory protein, for head and neck cancer patients with chemotherapy-related oral mucositis |
| title_full | Efficacy of GMI, a fungal immunomodulatory protein, for head and neck cancer patients with chemotherapy-related oral mucositis |
| title_fullStr | Efficacy of GMI, a fungal immunomodulatory protein, for head and neck cancer patients with chemotherapy-related oral mucositis |
| title_full_unstemmed | Efficacy of GMI, a fungal immunomodulatory protein, for head and neck cancer patients with chemotherapy-related oral mucositis |
| title_short | Efficacy of GMI, a fungal immunomodulatory protein, for head and neck cancer patients with chemotherapy-related oral mucositis |
| title_sort | efficacy of gmi a fungal immunomodulatory protein for head and neck cancer patients with chemotherapy related oral mucositis |
| url | http://journals.lww.com/10.1097/MD.0000000000029185 |
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