Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing
The increase in life expectancy and the increasing prevalence of diabetic disease and venous insufficiency lead to the increase of chronic wounds. The prevalence of ulcers ranges from 1% in the adult population to 3−5% in the over 65 years population, with 3−5.5% of the total hea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/2/179 |
| _version_ | 1811184614211846144 |
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| author | Giuseppina Sandri Angela Faccendini Marysol Longo Marco Ruggeri Silvia Rossi Maria Cristina Bonferoni Dalila Miele Adriele Prina-Mello Carola Aguzzi Cesar Viseras Franca Ferrari |
| author_facet | Giuseppina Sandri Angela Faccendini Marysol Longo Marco Ruggeri Silvia Rossi Maria Cristina Bonferoni Dalila Miele Adriele Prina-Mello Carola Aguzzi Cesar Viseras Franca Ferrari |
| author_sort | Giuseppina Sandri |
| collection | DOAJ |
| description | The increase in life expectancy and the increasing prevalence of diabetic disease and venous insufficiency lead to the increase of chronic wounds. The prevalence of ulcers ranges from 1% in the adult population to 3−5% in the over 65 years population, with 3−5.5% of the total healthcare expenditure, as recently estimated. The aim of this work was the design and the development of electrospun scaffolds, entirely based on biopolymers, loaded with montmorillonite (MMT) or halloysite (HNT) and intended for skin reparation and regeneration, as a 3D substrate mimicking the dermal ECM. The scaffolds were manufactured by means of electrospinning and were characterized for their chemico-physical and preclinical properties. The scaffolds proved to possess the capability to enhance fibroblast cells attachment and proliferation with negligible proinflammatory activity. The capability to facilitate the cell adhesion is probably due to their unique 3D structure which are assisting cell homing and would facilitate wound healing in vivo. |
| first_indexed | 2024-04-11T13:15:18Z |
| format | Article |
| id | doaj.art-dd98919de17d4ca48ae527b25c2c9985 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T13:15:18Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-dd98919de17d4ca48ae527b25c2c99852022-12-22T04:22:25ZengMDPI AGPharmaceutics1999-49232020-02-0112217910.3390/pharmaceutics12020179pharmaceutics12020179Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound HealingGiuseppina Sandri0Angela Faccendini1Marysol Longo2Marco Ruggeri3Silvia Rossi4Maria Cristina Bonferoni5Dalila Miele6Adriele Prina-Mello7Carola Aguzzi8Cesar Viseras9Franca Ferrari10Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyTrinity Translational Medicine Institute, Trinity College Dublin, Dublin 8, Dublin, IrelandDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Campus of Cartuja s/n, 18071 Granada, SpainDepartment of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Campus of Cartuja s/n, 18071 Granada, SpainDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyThe increase in life expectancy and the increasing prevalence of diabetic disease and venous insufficiency lead to the increase of chronic wounds. The prevalence of ulcers ranges from 1% in the adult population to 3−5% in the over 65 years population, with 3−5.5% of the total healthcare expenditure, as recently estimated. The aim of this work was the design and the development of electrospun scaffolds, entirely based on biopolymers, loaded with montmorillonite (MMT) or halloysite (HNT) and intended for skin reparation and regeneration, as a 3D substrate mimicking the dermal ECM. The scaffolds were manufactured by means of electrospinning and were characterized for their chemico-physical and preclinical properties. The scaffolds proved to possess the capability to enhance fibroblast cells attachment and proliferation with negligible proinflammatory activity. The capability to facilitate the cell adhesion is probably due to their unique 3D structure which are assisting cell homing and would facilitate wound healing in vivo.https://www.mdpi.com/1999-4923/12/2/179electrospinningchitosanchondroitin sulfatescaffoldsmontmorillonitehalloysitefibroblasts proliferationimmune response |
| spellingShingle | Giuseppina Sandri Angela Faccendini Marysol Longo Marco Ruggeri Silvia Rossi Maria Cristina Bonferoni Dalila Miele Adriele Prina-Mello Carola Aguzzi Cesar Viseras Franca Ferrari Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing Pharmaceutics electrospinning chitosan chondroitin sulfate scaffolds montmorillonite halloysite fibroblasts proliferation immune response |
| title | Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing |
| title_full | Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing |
| title_fullStr | Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing |
| title_full_unstemmed | Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing |
| title_short | Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing |
| title_sort | halloysite and montmorillonite loaded scaffolds as enhancers of chronic wound healing |
| topic | electrospinning chitosan chondroitin sulfate scaffolds montmorillonite halloysite fibroblasts proliferation immune response |
| url | https://www.mdpi.com/1999-4923/12/2/179 |
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