A one-year unisexual Schistosoma mansoni infection causes pathologic organ alterations and persistent non-polarized T cell-mediated inflammation in mice
In exhibiting gonochorism and phenotypic sexual dimorphism, Schistosoma spp. are unique among trematodes. Only females mating with male schistosomes can produce the highly immunogenic parasite eggs which determine the clinical picture of the disease schistosomiasis. The strong immune-modulatory effe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1010932/full |
| _version_ | 1811304752163586048 |
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| author | Martina Sombetzki Cindy Reinholdt Franziska Winkelmann Anne Rabes Nicole Koslowski Emil C. Reisinger |
| author_facet | Martina Sombetzki Cindy Reinholdt Franziska Winkelmann Anne Rabes Nicole Koslowski Emil C. Reisinger |
| author_sort | Martina Sombetzki |
| collection | DOAJ |
| description | In exhibiting gonochorism and phenotypic sexual dimorphism, Schistosoma spp. are unique among trematodes. Only females mating with male schistosomes can produce the highly immunogenic parasite eggs which determine the clinical picture of the disease schistosomiasis. The strong immune-modulatory effect of the eggs masks the influence of the adult worms. To shed light on the complexity of the immune response triggered by adult worms of Schistosoma mansoni, we performed a long-term unisexual infection experiment in mice. We were able to demonstrate that both male and female schistosomes can survive unpaired for one year in the murine host. Furthermore, unisexual S. mansoni infection leads to pronounced inflammation of the liver characterized by a non-polarized Th1/Th2 immune response, regardless of worm sex. |
| first_indexed | 2024-04-13T08:11:57Z |
| format | Article |
| id | doaj.art-dd9a73cf8a4b45fcab27fa154389ba86 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T08:11:57Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-dd9a73cf8a4b45fcab27fa154389ba862022-12-22T02:54:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10109321010932A one-year unisexual Schistosoma mansoni infection causes pathologic organ alterations and persistent non-polarized T cell-mediated inflammation in miceMartina SombetzkiCindy ReinholdtFranziska WinkelmannAnne RabesNicole KoslowskiEmil C. ReisingerIn exhibiting gonochorism and phenotypic sexual dimorphism, Schistosoma spp. are unique among trematodes. Only females mating with male schistosomes can produce the highly immunogenic parasite eggs which determine the clinical picture of the disease schistosomiasis. The strong immune-modulatory effect of the eggs masks the influence of the adult worms. To shed light on the complexity of the immune response triggered by adult worms of Schistosoma mansoni, we performed a long-term unisexual infection experiment in mice. We were able to demonstrate that both male and female schistosomes can survive unpaired for one year in the murine host. Furthermore, unisexual S. mansoni infection leads to pronounced inflammation of the liver characterized by a non-polarized Th1/Th2 immune response, regardless of worm sex.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1010932/fullunisexual infectionnon-polarzzed T-cell responseschistosoma mansonihepatitis (general)longterm infection |
| spellingShingle | Martina Sombetzki Cindy Reinholdt Franziska Winkelmann Anne Rabes Nicole Koslowski Emil C. Reisinger A one-year unisexual Schistosoma mansoni infection causes pathologic organ alterations and persistent non-polarized T cell-mediated inflammation in mice Frontiers in Immunology unisexual infection non-polarzzed T-cell response schistosoma mansoni hepatitis (general) longterm infection |
| title | A one-year unisexual Schistosoma mansoni infection causes pathologic organ alterations and persistent non-polarized T cell-mediated inflammation in mice |
| title_full | A one-year unisexual Schistosoma mansoni infection causes pathologic organ alterations and persistent non-polarized T cell-mediated inflammation in mice |
| title_fullStr | A one-year unisexual Schistosoma mansoni infection causes pathologic organ alterations and persistent non-polarized T cell-mediated inflammation in mice |
| title_full_unstemmed | A one-year unisexual Schistosoma mansoni infection causes pathologic organ alterations and persistent non-polarized T cell-mediated inflammation in mice |
| title_short | A one-year unisexual Schistosoma mansoni infection causes pathologic organ alterations and persistent non-polarized T cell-mediated inflammation in mice |
| title_sort | one year unisexual schistosoma mansoni infection causes pathologic organ alterations and persistent non polarized t cell mediated inflammation in mice |
| topic | unisexual infection non-polarzzed T-cell response schistosoma mansoni hepatitis (general) longterm infection |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1010932/full |
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