Characterization of Metabolic Correlations of Ursodeoxycholic Acid with Other Bile Acid Species through In Vitro Sequential Metabolism and Isomer-Focused Identification

Characterization of Metabolic Correlations of Ursodeoxycholic Acid with Other Bile Acid Species through In Vitro Sequential Metabolism and Isomer-Focused Identification

As a first-line agent for cholestasis treatment in a clinic, ursodeoxycholic acid rectifies the perturbed bile acids (BAs) submetabolome in a holistic manner. Considering the endogenous distribution of ursodeoxycholic acid and extensive occurrences of isomeric metabolites, it is challenging to point...

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Bibliographic Details
Main Authors: Wei Li, Wei Chen, Xiaoya Niu, Chen Zhao, Pengfei Tu, Jun Li, Wenjing Liu, Yuelin Song
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Molecules
Subjects:
ursodeoxycholic acid
metabolites
isomeric identification
conjugation site
squared energy-resolved mass spectrometry
Online Access:https://www.mdpi.com/1420-3049/28/12/4801

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