Epidermal Barrier Development via Corneoptosis: A Unique Form of Cell Death in Stratum Granulosum Cells
Epidermal development is responsible for the formation of the outermost layer of the skin, the epidermis. The establishment of the epidermal barrier is a critical aspect of mammalian development. Proper formation of the epidermis, which is composed of stratified squamous epithelial cells, is essenti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Journal of Developmental Biology |
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| Online Access: | https://www.mdpi.com/2221-3759/11/4/43 |
| _version_ | 1827574519619911680 |
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| author | Takeshi Matsui |
| author_facet | Takeshi Matsui |
| author_sort | Takeshi Matsui |
| collection | DOAJ |
| description | Epidermal development is responsible for the formation of the outermost layer of the skin, the epidermis. The establishment of the epidermal barrier is a critical aspect of mammalian development. Proper formation of the epidermis, which is composed of stratified squamous epithelial cells, is essential for the survival of terrestrial vertebrates because it acts as a crucial protective barrier against external threats such as pathogens, toxins, and physical trauma. In mammals, epidermal development begins from the embryonic surface ectoderm, which gives rise to the basal layer of the epidermis. This layer undergoes a series of complex processes that lead to the formation of subsequent layers, including the stratum intermedium, stratum spinosum, stratum granulosum, and stratum corneum. The stratum corneum, which is the topmost layer of the epidermis, is formed by corneoptosis, a specialized form of cell death. This process involves the transformation of epidermal keratinocytes in the granular layer into flattened dead cells, which constitute the protective barrier. In this review, we focus on the intricate mechanisms that drive the development and establishment of the mammalian epidermis to gain insight into the complex processes that govern this vital biological system. |
| first_indexed | 2024-03-08T20:39:17Z |
| format | Article |
| id | doaj.art-dda0096609b946c5956ccf5b5702f278 |
| institution | Directory Open Access Journal |
| issn | 2221-3759 |
| language | English |
| last_indexed | 2024-03-08T20:39:17Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Developmental Biology |
| spelling | doaj.art-dda0096609b946c5956ccf5b5702f2782023-12-22T14:17:56ZengMDPI AGJournal of Developmental Biology2221-37592023-11-011144310.3390/jdb11040043Epidermal Barrier Development via Corneoptosis: A Unique Form of Cell Death in Stratum Granulosum CellsTakeshi Matsui0Laboratory for Evolutionary Cell Biology of the Skin, School of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1, Katakura-cho, Tokyo 192-0982, JapanEpidermal development is responsible for the formation of the outermost layer of the skin, the epidermis. The establishment of the epidermal barrier is a critical aspect of mammalian development. Proper formation of the epidermis, which is composed of stratified squamous epithelial cells, is essential for the survival of terrestrial vertebrates because it acts as a crucial protective barrier against external threats such as pathogens, toxins, and physical trauma. In mammals, epidermal development begins from the embryonic surface ectoderm, which gives rise to the basal layer of the epidermis. This layer undergoes a series of complex processes that lead to the formation of subsequent layers, including the stratum intermedium, stratum spinosum, stratum granulosum, and stratum corneum. The stratum corneum, which is the topmost layer of the epidermis, is formed by corneoptosis, a specialized form of cell death. This process involves the transformation of epidermal keratinocytes in the granular layer into flattened dead cells, which constitute the protective barrier. In this review, we focus on the intricate mechanisms that drive the development and establishment of the mammalian epidermis to gain insight into the complex processes that govern this vital biological system.https://www.mdpi.com/2221-3759/11/4/43epidermal developmentstratum granulosumstratum corneumepidermal barriercorneoptoiscornification |
| spellingShingle | Takeshi Matsui Epidermal Barrier Development via Corneoptosis: A Unique Form of Cell Death in Stratum Granulosum Cells Journal of Developmental Biology epidermal development stratum granulosum stratum corneum epidermal barrier corneoptois cornification |
| title | Epidermal Barrier Development via Corneoptosis: A Unique Form of Cell Death in Stratum Granulosum Cells |
| title_full | Epidermal Barrier Development via Corneoptosis: A Unique Form of Cell Death in Stratum Granulosum Cells |
| title_fullStr | Epidermal Barrier Development via Corneoptosis: A Unique Form of Cell Death in Stratum Granulosum Cells |
| title_full_unstemmed | Epidermal Barrier Development via Corneoptosis: A Unique Form of Cell Death in Stratum Granulosum Cells |
| title_short | Epidermal Barrier Development via Corneoptosis: A Unique Form of Cell Death in Stratum Granulosum Cells |
| title_sort | epidermal barrier development via corneoptosis a unique form of cell death in stratum granulosum cells |
| topic | epidermal development stratum granulosum stratum corneum epidermal barrier corneoptois cornification |
| url | https://www.mdpi.com/2221-3759/11/4/43 |
| work_keys_str_mv | AT takeshimatsui epidermalbarrierdevelopmentviacorneoptosisauniqueformofcelldeathinstratumgranulosumcells |