A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture

Vascular endothelial cells (ECs) derived from the central nervous system (CNS) variably lose their unique barrier properties during in vitro culture, hindering the development of robust assays for blood-brain barrier (BBB) function, including drug permeability and extrusion assays. In previous work...

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Bibliographic Details
Main Authors: Mark F Sabbagh, Jeremy Nathans
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/51276