Abnormal cortical atrophy and functional connectivity are associated with depression in Parkinson’s disease
ObjectiveThis study aimed to investigate the association of altered cortical thickness and functional connectivity (FC) with depression in Parkinson’s disease (PD).Materials and methodsA total of 26 non-depressed PD patients (PD-ND), 30 PD patients with minor depression (PD-MnD), 32 PD patients with...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.957997/full |
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| author | Weifang Yin Anming Li Baiyuan Yang Chao Gao Yanfei Hu Zhenglong Luo Yuxia Li Yongyun Zhu Chuanbin Zhou Hui Ren Shimei Li Xinglong Yang Xinglong Yang Xinglong Yang |
| author_facet | Weifang Yin Anming Li Baiyuan Yang Chao Gao Yanfei Hu Zhenglong Luo Yuxia Li Yongyun Zhu Chuanbin Zhou Hui Ren Shimei Li Xinglong Yang Xinglong Yang Xinglong Yang |
| author_sort | Weifang Yin |
| collection | DOAJ |
| description | ObjectiveThis study aimed to investigate the association of altered cortical thickness and functional connectivity (FC) with depression in Parkinson’s disease (PD).Materials and methodsA total of 26 non-depressed PD patients (PD-ND), 30 PD patients with minor depression (PD-MnD), 32 PD patients with major depression (PD-MDD), and 30 healthy controls (HC) were enrolled. Differences in cortical thickness among the four groups were assessed, and the results were used to analyze FC differences in regions of cortical atrophy. Binary logistic regression and receiver operating characteristic (ROC) curve analyses were also performed to identify clinical features and neuroimaging biomarkers that might help in the prediction of PD-MDD.ResultsPatients with PD-MDD showed decreased cortical thickness compared to patients with PD-ND in the left superior temporal and right rostral middle frontal gyri (RMFG), as well as weak FC between the left superior temporal gyrus and right cerebellum posterior lobe and between right RMFG and right inferior frontal gyrus and insula. The combination of cortical thickness, FC, and basic clinical features showed strong potential for predicting PD-MDD based on the area under the ROC curve (0.927, 95% CI 0.854–0.999, p < 0.001).ConclusionPatients with PD-MDD show extensive cortical atrophy and FC alterations, suggesting that cortical thickness and FC may be neuroimaging-based diagnostic biomarkers for PD-MDD. |
| first_indexed | 2024-04-14T03:07:34Z |
| format | Article |
| id | doaj.art-dda55b490d5340ddaa413f763eb20366 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-14T03:07:34Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-dda55b490d5340ddaa413f763eb203662022-12-22T02:15:41ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-08-011410.3389/fnagi.2022.957997957997Abnormal cortical atrophy and functional connectivity are associated with depression in Parkinson’s diseaseWeifang Yin0Anming Li1Baiyuan Yang2Chao Gao3Yanfei Hu4Zhenglong Luo5Yuxia Li6Yongyun Zhu7Chuanbin Zhou8Hui Ren9Shimei Li10Xinglong Yang11Xinglong Yang12Xinglong Yang13Department of Geriatric Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Geriatric Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Neurology, Chengdu Seventh People’s Hospital, Chengdu, ChinaDepartment of Radiology, First Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Radiology, First Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Geriatric Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Geriatric Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Geriatric Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Geriatric Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Geriatric Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, ChinaDepartment of Anesthesia, Kunming Xishan District People’s Hospital, Kunming, ChinaDepartment of Geriatric Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, ChinaYunnan Provincial Clinical Research Center for Neurological Diseases, Kunming, ChinaYunnan Province Clinical Research Center for Geriatric Disease, Kunming, ChinaObjectiveThis study aimed to investigate the association of altered cortical thickness and functional connectivity (FC) with depression in Parkinson’s disease (PD).Materials and methodsA total of 26 non-depressed PD patients (PD-ND), 30 PD patients with minor depression (PD-MnD), 32 PD patients with major depression (PD-MDD), and 30 healthy controls (HC) were enrolled. Differences in cortical thickness among the four groups were assessed, and the results were used to analyze FC differences in regions of cortical atrophy. Binary logistic regression and receiver operating characteristic (ROC) curve analyses were also performed to identify clinical features and neuroimaging biomarkers that might help in the prediction of PD-MDD.ResultsPatients with PD-MDD showed decreased cortical thickness compared to patients with PD-ND in the left superior temporal and right rostral middle frontal gyri (RMFG), as well as weak FC between the left superior temporal gyrus and right cerebellum posterior lobe and between right RMFG and right inferior frontal gyrus and insula. The combination of cortical thickness, FC, and basic clinical features showed strong potential for predicting PD-MDD based on the area under the ROC curve (0.927, 95% CI 0.854–0.999, p < 0.001).ConclusionPatients with PD-MDD show extensive cortical atrophy and FC alterations, suggesting that cortical thickness and FC may be neuroimaging-based diagnostic biomarkers for PD-MDD.https://www.frontiersin.org/articles/10.3389/fnagi.2022.957997/fullParkinson’s diseasedepressioncortical atrophyfunctional connectivityneuroimaging biomarkers |
| spellingShingle | Weifang Yin Anming Li Baiyuan Yang Chao Gao Yanfei Hu Zhenglong Luo Yuxia Li Yongyun Zhu Chuanbin Zhou Hui Ren Shimei Li Xinglong Yang Xinglong Yang Xinglong Yang Abnormal cortical atrophy and functional connectivity are associated with depression in Parkinson’s disease Frontiers in Aging Neuroscience Parkinson’s disease depression cortical atrophy functional connectivity neuroimaging biomarkers |
| title | Abnormal cortical atrophy and functional connectivity are associated with depression in Parkinson’s disease |
| title_full | Abnormal cortical atrophy and functional connectivity are associated with depression in Parkinson’s disease |
| title_fullStr | Abnormal cortical atrophy and functional connectivity are associated with depression in Parkinson’s disease |
| title_full_unstemmed | Abnormal cortical atrophy and functional connectivity are associated with depression in Parkinson’s disease |
| title_short | Abnormal cortical atrophy and functional connectivity are associated with depression in Parkinson’s disease |
| title_sort | abnormal cortical atrophy and functional connectivity are associated with depression in parkinson s disease |
| topic | Parkinson’s disease depression cortical atrophy functional connectivity neuroimaging biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.957997/full |
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