Protective and curative effects of Cestrum nocturnum on rabbit kidney
The objective of current study was to evaluate the nephroprotective and nephrocurative effects of methanolic extract of Cestrum nocturnum leaves in rabbits. Gentamicin (80 mg/kg/day) was administered intramuscularly to induce nephrotoxicity. The induction was assessed by biochemical and histopatholo...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2017-08-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/32410 |
| _version_ | 1819135474208342016 |
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| author | Uzma Saleem Nauman Ali Bashir Ahmad |
| author_facet | Uzma Saleem Nauman Ali Bashir Ahmad |
| author_sort | Uzma Saleem |
| collection | DOAJ |
| description | The objective of current study was to evaluate the nephroprotective and nephrocurative effects of methanolic extract of Cestrum nocturnum leaves in rabbits. Gentamicin (80 mg/kg/day) was administered intramuscularly to induce nephrotoxicity. The induction was assessed by biochemical and histopathological analysis. Methanolic extract (100, 300 or 500 mg/kg) was given orally with gentamicin for 25 days in nephroprotective study whereas in nephrocurative study, gentamicin was administered intramuscularly for first 10 days and for next 15 days only methanolic extract (100, 300 or 500 mg/kg, orally) was administered. A significant decrease was found in total oxidant status, blood urea nitrogen, serum creatinine and uric acid levels whereas albumin level increased significantly. Histopathological studies also revealed nephroprotective and nephrocurative effects. In conclusion, the methanolic extract of C. nocturnum leaves exhibited significant nephro-protective and nephrocurative effects in experimental animal.
Video Clip of Methodology:
6 min 47 sec: Full Screen Alternate |
| first_indexed | 2024-12-22T10:19:39Z |
| format | Article |
| id | doaj.art-dda641bc13ec4835b61772dc9ab02bb7 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-22T10:19:39Z |
| publishDate | 2017-08-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-dda641bc13ec4835b61772dc9ab02bb72022-12-21T18:29:40ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882017-08-0112310.3329/bjp.v12i3.3241021489Protective and curative effects of Cestrum nocturnum on rabbit kidneyUzma Saleem0Nauman Ali1Bashir Ahmad2Faculty of Pharmaceutical Sciences, Govt. College University, FaisalabadFaculty of Pharmaceutical Sciences, Govt. College University, FaisalabadRiphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, LahoreThe objective of current study was to evaluate the nephroprotective and nephrocurative effects of methanolic extract of Cestrum nocturnum leaves in rabbits. Gentamicin (80 mg/kg/day) was administered intramuscularly to induce nephrotoxicity. The induction was assessed by biochemical and histopathological analysis. Methanolic extract (100, 300 or 500 mg/kg) was given orally with gentamicin for 25 days in nephroprotective study whereas in nephrocurative study, gentamicin was administered intramuscularly for first 10 days and for next 15 days only methanolic extract (100, 300 or 500 mg/kg, orally) was administered. A significant decrease was found in total oxidant status, blood urea nitrogen, serum creatinine and uric acid levels whereas albumin level increased significantly. Histopathological studies also revealed nephroprotective and nephrocurative effects. In conclusion, the methanolic extract of C. nocturnum leaves exhibited significant nephro-protective and nephrocurative effects in experimental animal. Video Clip of Methodology: 6 min 47 sec: Full Screen Alternatehttps://www.banglajol.info/index.php/BJP/article/view/32410C. nocturnumNephroprotectiveNephrocurative |
| spellingShingle | Uzma Saleem Nauman Ali Bashir Ahmad Protective and curative effects of Cestrum nocturnum on rabbit kidney Bangladesh Journal of Pharmacology C. nocturnum Nephroprotective Nephrocurative |
| title | Protective and curative effects of Cestrum nocturnum on rabbit kidney |
| title_full | Protective and curative effects of Cestrum nocturnum on rabbit kidney |
| title_fullStr | Protective and curative effects of Cestrum nocturnum on rabbit kidney |
| title_full_unstemmed | Protective and curative effects of Cestrum nocturnum on rabbit kidney |
| title_short | Protective and curative effects of Cestrum nocturnum on rabbit kidney |
| title_sort | protective and curative effects of cestrum nocturnum on rabbit kidney |
| topic | C. nocturnum Nephroprotective Nephrocurative |
| url | https://www.banglajol.info/index.php/BJP/article/view/32410 |
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