In-silico analysis of TCGA data showing multiple POLE-like favourable subgroups overlapping with TP53 mutated endometrial cancer: Implications for clinical practice in low and middle-income countries

In-silico analysis of TCGA data showing multiple POLE-like favourable subgroups overlapping with TP53 mutated endometrial cancer: Implications for clinical practice in low and middle-income countries

Introduction: The Cancer Genome Atlas cohort of endometrial carcinoma (TCGA-UCEC) includes almost 40% TP53-mutants encompassing missense and truncated variants. TCGA revealed ‘POLE’, characterized by POLE gene bearing exonuclease domain mutation (EDM), as the prognostically best molecular profile. T...

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Bibliographic Details
Main Authors: Damayanti Das Ghosh, Rahul Roy Chowdhury, Rajeswari Dutta, Indranil Mukhopadhyay, Asima Mukhopadhyay, Susanta Roychoudhury
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Gynecologic Oncology Reports
Subjects:
Endometrial cancer
TCGA
TP53
POLE-like
Prognosis
Low and middle-income countries
Online Access:http://www.sciencedirect.com/science/article/pii/S2352578923000784

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