Genomic Epidemiology of Early SARS-CoV-2 Transmission Dynamics, Gujarat, India
Limited genomic sampling in many high-incidence countries has impeded studies of severe respiratory syndrome coronavirus 2 (SARS-CoV-2) genomic epidemiology. Consequently, critical questions remain about the generation and global distribution of virus genetic diversity. We investigated SARS-CoV-2 t...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2022-04-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/28/4/21-2053_article |
| _version_ | 1818775317408382976 |
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| author | Jayna Raghwani Louis du Plessis John T. McCrone Sarah C. Hill Kris V. Parag Julien Thézé Dinesh Kumar Apurva Puvar Ramesh Pandit Oliver G. Pybus Guillaume Fournié Madhvi Joshi Chaitanya Joshi |
| author_facet | Jayna Raghwani Louis du Plessis John T. McCrone Sarah C. Hill Kris V. Parag Julien Thézé Dinesh Kumar Apurva Puvar Ramesh Pandit Oliver G. Pybus Guillaume Fournié Madhvi Joshi Chaitanya Joshi |
| author_sort | Jayna Raghwani |
| collection | DOAJ |
| description |
Limited genomic sampling in many high-incidence countries has impeded studies of severe respiratory syndrome coronavirus 2 (SARS-CoV-2) genomic epidemiology. Consequently, critical questions remain about the generation and global distribution of virus genetic diversity. We investigated SARS-CoV-2 transmission dynamics in Gujarat, India, during the state’s first epidemic wave to shed light on spread of the virus in one of the regions hardest hit by the pandemic. By integrating case data and 434 whole-genome sequences sampled across 20 districts, we reconstructed the epidemic dynamics and spatial spread of SARS-CoV-2 in Gujarat. Our findings indicate global and regional connectivity and population density were major drivers of the Gujarat outbreak. We detected >100 virus lineage introductions, most of which appear to be associated with international travel. Within Gujarat, virus dissemination occurred predominantly from densely populated regions to geographically proximate locations that had low population density, suggesting that urban centers contributed disproportionately to virus spread.
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| first_indexed | 2024-12-18T10:55:07Z |
| format | Article |
| id | doaj.art-dda72a171cde471ab0bda7baf89135e7 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-18T10:55:07Z |
| publishDate | 2022-04-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-dda72a171cde471ab0bda7baf89135e72022-12-21T21:10:21ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592022-04-0128475175810.3201/eid2804.212053Genomic Epidemiology of Early SARS-CoV-2 Transmission Dynamics, Gujarat, IndiaJayna RaghwaniLouis du PlessisJohn T. McCroneSarah C. HillKris V. ParagJulien ThézéDinesh KumarApurva PuvarRamesh PanditOliver G. PybusGuillaume FourniéMadhvi JoshiChaitanya Joshi Limited genomic sampling in many high-incidence countries has impeded studies of severe respiratory syndrome coronavirus 2 (SARS-CoV-2) genomic epidemiology. Consequently, critical questions remain about the generation and global distribution of virus genetic diversity. We investigated SARS-CoV-2 transmission dynamics in Gujarat, India, during the state’s first epidemic wave to shed light on spread of the virus in one of the regions hardest hit by the pandemic. By integrating case data and 434 whole-genome sequences sampled across 20 districts, we reconstructed the epidemic dynamics and spatial spread of SARS-CoV-2 in Gujarat. Our findings indicate global and regional connectivity and population density were major drivers of the Gujarat outbreak. We detected >100 virus lineage introductions, most of which appear to be associated with international travel. Within Gujarat, virus dissemination occurred predominantly from densely populated regions to geographically proximate locations that had low population density, suggesting that urban centers contributed disproportionately to virus spread. https://wwwnc.cdc.gov/eid/article/28/4/21-2053_articleCOVID-19genomic epidemiologysevere acute respiratory syndrome coronavirus 2SARS-CoV-2coronavirusesvirus |
| spellingShingle | Jayna Raghwani Louis du Plessis John T. McCrone Sarah C. Hill Kris V. Parag Julien Thézé Dinesh Kumar Apurva Puvar Ramesh Pandit Oliver G. Pybus Guillaume Fournié Madhvi Joshi Chaitanya Joshi Genomic Epidemiology of Early SARS-CoV-2 Transmission Dynamics, Gujarat, India Emerging Infectious Diseases COVID-19 genomic epidemiology severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 coronaviruses virus |
| title | Genomic Epidemiology of Early SARS-CoV-2 Transmission Dynamics, Gujarat, India |
| title_full | Genomic Epidemiology of Early SARS-CoV-2 Transmission Dynamics, Gujarat, India |
| title_fullStr | Genomic Epidemiology of Early SARS-CoV-2 Transmission Dynamics, Gujarat, India |
| title_full_unstemmed | Genomic Epidemiology of Early SARS-CoV-2 Transmission Dynamics, Gujarat, India |
| title_short | Genomic Epidemiology of Early SARS-CoV-2 Transmission Dynamics, Gujarat, India |
| title_sort | genomic epidemiology of early sars cov 2 transmission dynamics gujarat india |
| topic | COVID-19 genomic epidemiology severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 coronaviruses virus |
| url | https://wwwnc.cdc.gov/eid/article/28/4/21-2053_article |
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