Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies
Abstract Autophagy is an essential cellular homeostasis pathway initiated by multiple stimuli ranging from nutrient deprivation to viral infection, playing a key role in human health and disease. At present, a growing number of evidence suggests a role of autophagy as a primitive innate immune form...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-023-01893-w |
| _version_ | 1797398172059828224 |
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| author | Manuela Giansanti Tobias Theinert Sarah Katharina Boeing Dorothee Haas Paul-Gerhardt Schlegel Paola Vacca Francesca Nazio Ignazio Caruana |
| author_facet | Manuela Giansanti Tobias Theinert Sarah Katharina Boeing Dorothee Haas Paul-Gerhardt Schlegel Paola Vacca Francesca Nazio Ignazio Caruana |
| author_sort | Manuela Giansanti |
| collection | DOAJ |
| description | Abstract Autophagy is an essential cellular homeostasis pathway initiated by multiple stimuli ranging from nutrient deprivation to viral infection, playing a key role in human health and disease. At present, a growing number of evidence suggests a role of autophagy as a primitive innate immune form of defense for eukaryotic cells, interacting with components of innate immune signaling pathways and regulating thymic selection, antigen presentation, cytokine production and T/NK cell homeostasis. In cancer, autophagy is intimately involved in the immunological control of tumor progression and response to therapy. However, very little is known about the role and impact of autophagy in T and NK cells, the main players in the active fight against infections and tumors. Important questions are emerging: what role does autophagy play on T/NK cells? Could its modulation lead to any advantages? Could specific targeting of autophagy on tumor cells (blocking) and T/NK cells (activation) be a new intervention strategy? In this review, we debate preclinical studies that have identified autophagy as a key regulator of immune responses by modulating the functions of different immune cells and discuss the redundancy or diversity among the subpopulations of both T and NK cells in physiologic context and in cancer. |
| first_indexed | 2024-03-09T01:20:54Z |
| format | Article |
| id | doaj.art-dda7511bdfcc402497479b670edc5983 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-03-09T01:20:54Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-dda7511bdfcc402497479b670edc59832023-12-10T12:09:46ZengBMCMolecular Cancer1476-45982023-12-0122112610.1186/s12943-023-01893-wExploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapiesManuela Giansanti0Tobias Theinert1Sarah Katharina Boeing2Dorothee Haas3Paul-Gerhardt Schlegel4Paola Vacca5Francesca Nazio6Ignazio Caruana7Immunology Research Area, Innate Lymphoid Cells Unit, Bambino Gesù Children’s Hospital (IRCCS)Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital WürzburgDepartment of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital WürzburgDepartment of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital WürzburgDepartment of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital WürzburgImmunology Research Area, Innate Lymphoid Cells Unit, Bambino Gesù Children’s Hospital (IRCCS)Immunology Research Area, Innate Lymphoid Cells Unit, Bambino Gesù Children’s Hospital (IRCCS)Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital WürzburgAbstract Autophagy is an essential cellular homeostasis pathway initiated by multiple stimuli ranging from nutrient deprivation to viral infection, playing a key role in human health and disease. At present, a growing number of evidence suggests a role of autophagy as a primitive innate immune form of defense for eukaryotic cells, interacting with components of innate immune signaling pathways and regulating thymic selection, antigen presentation, cytokine production and T/NK cell homeostasis. In cancer, autophagy is intimately involved in the immunological control of tumor progression and response to therapy. However, very little is known about the role and impact of autophagy in T and NK cells, the main players in the active fight against infections and tumors. Important questions are emerging: what role does autophagy play on T/NK cells? Could its modulation lead to any advantages? Could specific targeting of autophagy on tumor cells (blocking) and T/NK cells (activation) be a new intervention strategy? In this review, we debate preclinical studies that have identified autophagy as a key regulator of immune responses by modulating the functions of different immune cells and discuss the redundancy or diversity among the subpopulations of both T and NK cells in physiologic context and in cancer.https://doi.org/10.1186/s12943-023-01893-wAutophagyEffector cellsMitophagyMetabolismT and NK development |
| spellingShingle | Manuela Giansanti Tobias Theinert Sarah Katharina Boeing Dorothee Haas Paul-Gerhardt Schlegel Paola Vacca Francesca Nazio Ignazio Caruana Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies Molecular Cancer Autophagy Effector cells Mitophagy Metabolism T and NK development |
| title | Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies |
| title_full | Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies |
| title_fullStr | Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies |
| title_full_unstemmed | Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies |
| title_short | Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies |
| title_sort | exploiting autophagy balance in t and nk cells as a new strategy to implement adoptive cell therapies |
| topic | Autophagy Effector cells Mitophagy Metabolism T and NK development |
| url | https://doi.org/10.1186/s12943-023-01893-w |
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