Slitrk missense mutations associated with neuropsychiatric disorders distinctively impair Slitrk trafficking and synapse formation

Slitrk missense mutations associated with neuropsychiatric disorders distinctively impair Slitrk trafficking and synapse formation

Slitrks are a six-member family of synapse organizers that control excitatory and inhibitory synapse formation by forming trans-synaptic adhesions with LAR receptor protein tyrosine phosphatases (PTPs). Intriguingly, genetic mutations of Slitrks have been associated with a multitude of neuropsychiat...

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Bibliographic Details
Main Authors: Hyeyeon Kang, Kyung Ah Han, Seong Youn Won, Ho Min Kim, Young-Ho Lee, Jaewon Ko, JI WON UM
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Schizophrenia
synapse formation
Tourette’s Syndrome
transmembrane protein
Slitrks
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00104/full

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