Effects of Histamine Receptor Antagonist Cetirizine on Orthodontic Tooth Movement
Many patients regularly take histamine receptor antagonists, such as cetirizine, to prevent allergic reactions, but these antiallergic drugs may have inadvertent effects on orthodontic treatment. In previous studies, histamine has been shown to modulate the sterile inflammatory reaction underlying o...
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MDPI AG
2020-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/8/12/583 |
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| author | Gregor Sperl Johanna Gattner James Deschner Michael Wolf Peter Proff Agnes Schröder Christian Kirschneck |
| author_facet | Gregor Sperl Johanna Gattner James Deschner Michael Wolf Peter Proff Agnes Schröder Christian Kirschneck |
| author_sort | Gregor Sperl |
| collection | DOAJ |
| description | Many patients regularly take histamine receptor antagonists, such as cetirizine, to prevent allergic reactions, but these antiallergic drugs may have inadvertent effects on orthodontic treatment. In previous studies, histamine has been shown to modulate the sterile inflammatory reaction underlying orthodontic tooth movement. Pertinent effects of histamine antagonization via cetirizine during orthodontic treatment, however, have not been adequately investigated. We thus treated male Fischer344 rats either with tap water (control group) or cetirizine by daily oral gavage corresponding to the clinically used human dosage adjusted to the rat metabolism (0.87 mg/kg) or to a previously published high dosage of cetirizine (3 mg/kg). Experimental anterior movement of the first upper left molar was induced by insertion of a nickel-titanium (NiTi) coil spring (0.25 N) between the molar and the upper incisors. Cone-beam computed tomography (CBCT), micro-computed tomography (µCT) images, as well as histological hematoxylin-eosin (HE), and tartrate-resistant acid phosphatase (TRAP) stainings were used to assess the extent of tooth movement, cranial growth, periodontal bone loss, root resorptions, and osteoclast activity in the periodontal ligament. Both investigated cetirizine dosages had no impact on the weight gain of the animals and, thus, animal welfare. Neither the extent of tooth movement, nor cranial growth, nor root resorption, nor periodontal bone loss were significantly influenced by the cetirizine dosages investigated. We, thus, conclude that histamine receptor antagonist cetirizine can be used during orthodontic treatment to prevent allergic reactions without clinically relevant side effects on orthodontic tooth movement. |
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| last_indexed | 2024-03-10T14:16:01Z |
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| spelling | doaj.art-dda80d81243842b2b1dc0f695401d8622023-11-20T23:51:39ZengMDPI AGBiomedicines2227-90592020-12-0181258310.3390/biomedicines8120583Effects of Histamine Receptor Antagonist Cetirizine on Orthodontic Tooth MovementGregor Sperl0Johanna Gattner1James Deschner2Michael Wolf3Peter Proff4Agnes Schröder5Christian Kirschneck6Department of Orthodontics, University Hospital Regensburg, 93053 Regensburg, GermanyDepartment of Orthodontics, University Hospital Regensburg, 93053 Regensburg, GermanyDepartment of Periodontology and Operative Dentistry, University of Mainz, 55131 Mainz, GermanyDepartment of Orthodontics, University Hospital RWTH Aachen, 52062 Aachen, GermanyDepartment of Orthodontics, University Hospital Regensburg, 93053 Regensburg, GermanyDepartment of Orthodontics, University Hospital Regensburg, 93053 Regensburg, GermanyDepartment of Orthodontics, University Hospital Regensburg, 93053 Regensburg, GermanyMany patients regularly take histamine receptor antagonists, such as cetirizine, to prevent allergic reactions, but these antiallergic drugs may have inadvertent effects on orthodontic treatment. In previous studies, histamine has been shown to modulate the sterile inflammatory reaction underlying orthodontic tooth movement. Pertinent effects of histamine antagonization via cetirizine during orthodontic treatment, however, have not been adequately investigated. We thus treated male Fischer344 rats either with tap water (control group) or cetirizine by daily oral gavage corresponding to the clinically used human dosage adjusted to the rat metabolism (0.87 mg/kg) or to a previously published high dosage of cetirizine (3 mg/kg). Experimental anterior movement of the first upper left molar was induced by insertion of a nickel-titanium (NiTi) coil spring (0.25 N) between the molar and the upper incisors. Cone-beam computed tomography (CBCT), micro-computed tomography (µCT) images, as well as histological hematoxylin-eosin (HE), and tartrate-resistant acid phosphatase (TRAP) stainings were used to assess the extent of tooth movement, cranial growth, periodontal bone loss, root resorptions, and osteoclast activity in the periodontal ligament. Both investigated cetirizine dosages had no impact on the weight gain of the animals and, thus, animal welfare. Neither the extent of tooth movement, nor cranial growth, nor root resorption, nor periodontal bone loss were significantly influenced by the cetirizine dosages investigated. We, thus, conclude that histamine receptor antagonist cetirizine can be used during orthodontic treatment to prevent allergic reactions without clinically relevant side effects on orthodontic tooth movement.https://www.mdpi.com/2227-9059/8/12/583cetirizineorthodontic tooth movementhistamine receptor antagonistsµCT |
| spellingShingle | Gregor Sperl Johanna Gattner James Deschner Michael Wolf Peter Proff Agnes Schröder Christian Kirschneck Effects of Histamine Receptor Antagonist Cetirizine on Orthodontic Tooth Movement Biomedicines cetirizine orthodontic tooth movement histamine receptor antagonists µCT |
| title | Effects of Histamine Receptor Antagonist Cetirizine on Orthodontic Tooth Movement |
| title_full | Effects of Histamine Receptor Antagonist Cetirizine on Orthodontic Tooth Movement |
| title_fullStr | Effects of Histamine Receptor Antagonist Cetirizine on Orthodontic Tooth Movement |
| title_full_unstemmed | Effects of Histamine Receptor Antagonist Cetirizine on Orthodontic Tooth Movement |
| title_short | Effects of Histamine Receptor Antagonist Cetirizine on Orthodontic Tooth Movement |
| title_sort | effects of histamine receptor antagonist cetirizine on orthodontic tooth movement |
| topic | cetirizine orthodontic tooth movement histamine receptor antagonists µCT |
| url | https://www.mdpi.com/2227-9059/8/12/583 |
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