Phytochemical and pharmacological investigation of the ethanol extract of Byttneria pilosa Roxb.
Abstract Background Traditionally, the herb Byttneria pilosa Roxb. is used for bone fractures, boils, scabies, rheumatalgia, snake bites, syphilis, elephantiasis, poisoning, and eye infection. Scientific reports suggest that it has significant anti-inflammatory, analgesic, anti-diarrheal, anxiolytic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-01-01
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| Series: | Clinical Phytoscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40816-021-00333-w |
| _version_ | 1830402740178649088 |
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| author | Liton Sikder Md. Roich Khan Shanita Zaman Smrity Muhammad Torequl Islam Shams Ara Khan |
| author_facet | Liton Sikder Md. Roich Khan Shanita Zaman Smrity Muhammad Torequl Islam Shams Ara Khan |
| author_sort | Liton Sikder |
| collection | DOAJ |
| description | Abstract Background Traditionally, the herb Byttneria pilosa Roxb. is used for bone fractures, boils, scabies, rheumatalgia, snake bites, syphilis, elephantiasis, poisoning, and eye infection. Scientific reports suggest that it has significant anti-inflammatory, analgesic, anti-diarrheal, anxiolytic, locomotion, sedative and anti-obesity effects. This study aims at the investigation of the phytochemical and pharmacological properties of the ethanol extract of this herb. Methods Fresh whole plant was extracted with absolute ethanol. A preliminary phytochemical investigation was followed by the evaluation of thrombolytic, anti-inflammatory, and anti-nociceptive activities by applying human clotted blood lysis, egg albumin, and acetic acid-induced writhing models, respectively. Results Phytochemical investigation suggests that B. pilosa possesses alkaloids, flavonoids, glycosides, terpenoids, tannins, saponins, and reducing sugars. The extract exhibited clot lysis and anti-inflammatory effects in a concentration-dependent manner. B. pilosa extract at 250 and 500 mg/kg also showed significant (p < 0.05) dose-dependent anti-nociceptive activity in Swiss albino mice. Conclusion The B. pilosa ethanol extract contains many important secondary metabolites and has thrombolytic, anti-inflammatory, and anti-nociceptive activities. More research is necessary on this hopeful medicinal herb. |
| first_indexed | 2024-12-20T16:58:33Z |
| format | Article |
| id | doaj.art-dda9520ba2244131bb10be2f2444b76e |
| institution | Directory Open Access Journal |
| issn | 2199-1197 |
| language | English |
| last_indexed | 2024-12-20T16:58:33Z |
| publishDate | 2022-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Clinical Phytoscience |
| spelling | doaj.art-dda9520ba2244131bb10be2f2444b76e2022-12-21T19:32:39ZengSpringerOpenClinical Phytoscience2199-11972022-01-01811810.1186/s40816-021-00333-wPhytochemical and pharmacological investigation of the ethanol extract of Byttneria pilosa Roxb.Liton Sikder0Md. Roich Khan1Shanita Zaman Smrity2Muhammad Torequl Islam3Shams Ara Khan4Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityDepartment of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityDepartment of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityDepartment of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityDepartment of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityAbstract Background Traditionally, the herb Byttneria pilosa Roxb. is used for bone fractures, boils, scabies, rheumatalgia, snake bites, syphilis, elephantiasis, poisoning, and eye infection. Scientific reports suggest that it has significant anti-inflammatory, analgesic, anti-diarrheal, anxiolytic, locomotion, sedative and anti-obesity effects. This study aims at the investigation of the phytochemical and pharmacological properties of the ethanol extract of this herb. Methods Fresh whole plant was extracted with absolute ethanol. A preliminary phytochemical investigation was followed by the evaluation of thrombolytic, anti-inflammatory, and anti-nociceptive activities by applying human clotted blood lysis, egg albumin, and acetic acid-induced writhing models, respectively. Results Phytochemical investigation suggests that B. pilosa possesses alkaloids, flavonoids, glycosides, terpenoids, tannins, saponins, and reducing sugars. The extract exhibited clot lysis and anti-inflammatory effects in a concentration-dependent manner. B. pilosa extract at 250 and 500 mg/kg also showed significant (p < 0.05) dose-dependent anti-nociceptive activity in Swiss albino mice. Conclusion The B. pilosa ethanol extract contains many important secondary metabolites and has thrombolytic, anti-inflammatory, and anti-nociceptive activities. More research is necessary on this hopeful medicinal herb.https://doi.org/10.1186/s40816-021-00333-wByttneria pilosaAnti-inflammatoryAnti-nociceptiveClot lysis |
| spellingShingle | Liton Sikder Md. Roich Khan Shanita Zaman Smrity Muhammad Torequl Islam Shams Ara Khan Phytochemical and pharmacological investigation of the ethanol extract of Byttneria pilosa Roxb. Clinical Phytoscience Byttneria pilosa Anti-inflammatory Anti-nociceptive Clot lysis |
| title | Phytochemical and pharmacological investigation of the ethanol extract of Byttneria pilosa Roxb. |
| title_full | Phytochemical and pharmacological investigation of the ethanol extract of Byttneria pilosa Roxb. |
| title_fullStr | Phytochemical and pharmacological investigation of the ethanol extract of Byttneria pilosa Roxb. |
| title_full_unstemmed | Phytochemical and pharmacological investigation of the ethanol extract of Byttneria pilosa Roxb. |
| title_short | Phytochemical and pharmacological investigation of the ethanol extract of Byttneria pilosa Roxb. |
| title_sort | phytochemical and pharmacological investigation of the ethanol extract of byttneria pilosa roxb |
| topic | Byttneria pilosa Anti-inflammatory Anti-nociceptive Clot lysis |
| url | https://doi.org/10.1186/s40816-021-00333-w |
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