A Novel Insertion Mutation on Exon 20 of Epidermal Growth Factor Receptor, Conferring Resistance to Erlotinib

A Novel Insertion Mutation on Exon 20 of Epidermal Growth Factor Receptor, Conferring Resistance to Erlotinib

The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein tyrosine kinase receptor. The small-molecule tyrosine kinase receptor inhibitors (TKIs) are in clinical use to treat non-small cell lung cancer with EGFR mutations. Variable tumor responses to erlotinib and gefitinib have be...

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Bibliographic Details
Main Authors: Nawazish A. Khan, Saied Mirshahidi, Hamid R. Mirshahidi
Format: Article
Language:English
Published: Karger Publishers 2014-07-01
Series:Case Reports in Oncology
Subjects:
Epidermal growth factor receptor
Tyrosine kinase receptor inhibitors
Mutations
Exon 20
Non-small cell lung cancer
Erlotinib
Online Access:http://www.karger.com/Article/FullText/365325

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