DNA methylation modulated genetic variant effect on gene transcriptional regulation

DNA methylation modulated genetic variant effect on gene transcriptional regulation

Abstract Background Expression quantitative trait locus (eQTL) analysis has emerged as an important tool in elucidating the link between genetic variants and gene expression, thereby bridging the gap between risk SNPs and associated diseases. We recently identified and validated a specific case wher...

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Bibliographic Details
Main Authors: Yong Zeng, Rahi Jain, Magnus Lam, Musaddeque Ahmed, Haiyang Guo, Wenjie Xu, Yuan Zhong, Gong-Hong Wei, Wei Xu, Housheng Hansen He
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Genome Biology
Subjects:
SNP
CTCF
meCpG
eQTL
Memo-eQTL
Chromatin 3D structure
Online Access:https://doi.org/10.1186/s13059-023-03130-5

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