Small-molecule compound from AlphaScreen disrupts tau-glycan interface

Small-molecule compound from AlphaScreen disrupts tau-glycan interface

Tauopathies are neurodegenerative diseases characterized by intracellular abnormal tau deposits in the brain. Tau aggregates can propagate from one neuron to another in a prion-like manner, mediated by the interaction between tau and cell surface heparan sulfate proteoglycans. We developed an AlphaS...

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Bibliographic Details
Main Authors:	Shannon Faris, Weihua Jin, James Gibson, Anqesha Murray, Nathan Smith, Peng He, Fuming Zhang, Robert Linhardt, Chunyu Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Series:	Frontiers in Molecular Biosciences
Subjects:	drug discovery tau Alzheimer’s disease AlphaScreen heparan sulfate proteoglycan (HSPG) tauopathies
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.1083225/full

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