Gastric emptying during and following resolution of moderate diabetic ketoacidosis in type 1 diabetes: a case series
Introduction To use the ‘gold standard’ technique of scintigraphy to quantify gastric emptying (GE) as soon as practicable during an admission with diabetic ketoacidosis (DKA) and following its resolution at least 7 days later.Research design and methods Five patients with type 1 diabetes, age 29±12...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-04-01
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| Series: | BMJ Open Diabetes Research & Care |
| Online Access: | https://drc.bmj.com/content/12/2/e003854.full |
| _version_ | 1797224432073179136 |
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| author | Michael Horowitz Karen L Jones Christopher K Rayner Ryan J Jalleh Liza Phillips Mahesh M Umapathysivam Chinmay S Marathe Linda E Watson Michelle Bound |
| author_facet | Michael Horowitz Karen L Jones Christopher K Rayner Ryan J Jalleh Liza Phillips Mahesh M Umapathysivam Chinmay S Marathe Linda E Watson Michelle Bound |
| author_sort | Michael Horowitz |
| collection | DOAJ |
| description | Introduction To use the ‘gold standard’ technique of scintigraphy to quantify gastric emptying (GE) as soon as practicable during an admission with diabetic ketoacidosis (DKA) and following its resolution at least 7 days later.Research design and methods Five patients with type 1 diabetes, age 29±12 years; Body Mass Index 23±3 kg/m2; hemoglobin A1c 11.3%±1.9%, were studied during an admission with DKA and following its resolution. Solid and liquid GE were measured using scintigraphy. Solid emptying was assessed via the percentage intragastric retention at 100 min and that of liquid by the 50% emptying time.Results There was no difference in either solid or liquid GE at the initial study compared with the follow-up. Median (IQR) solid retention was 47±20 versus 38%±33%, respectively; p=0.31, and time to empty 50% of liquid was 37±25 min versus 35±15 min, p=0.31, at the initial and follow-up GE study, respectively.Conclusions GE of solids and liquids is not affected by moderate DKA, inferring that earlier reintroduction of oral intake may be appropriate. |
| first_indexed | 2024-04-24T13:53:01Z |
| format | Article |
| id | doaj.art-ddac9039836d4105a62ebfbf765cdee6 |
| institution | Directory Open Access Journal |
| issn | 2052-4897 |
| language | English |
| last_indexed | 2024-04-24T13:53:01Z |
| publishDate | 2024-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Diabetes Research & Care |
| spelling | doaj.art-ddac9039836d4105a62ebfbf765cdee62024-04-04T03:45:08ZengBMJ Publishing GroupBMJ Open Diabetes Research & Care2052-48972024-04-0112210.1136/bmjdrc-2023-003854Gastric emptying during and following resolution of moderate diabetic ketoacidosis in type 1 diabetes: a case seriesMichael Horowitz0Karen L Jones1Christopher K Rayner2Ryan J Jalleh3Liza Phillips4Mahesh M Umapathysivam5Chinmay S Marathe6Linda E Watson7Michelle Bound8The University of Adelaide, Adelaide, South Australia, AustraliaCentre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, AustraliaCentre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, AustraliaThe University of Adelaide Faculty of Health and Medical Sciences, Adelaide, South Australia, AustraliaMater Hospital Brisbane, Brisbane, Queensland, AustraliaThe University of Adelaide Faculty of Health and Medical Sciences, Adelaide, South Australia, AustraliaEndocrine and Metabolic Unit, The University of Adelaide Faculty of Health and Medical Sciences, Adelaide, South Australia, AustraliaDiscipline of Medicine, The University of Adelaide Faculty of Health and Medical Sciences, Adelaide, South Australia, AustraliaThe University of Adelaide Faculty of Health and Medical Sciences, Adelaide, South Australia, AustraliaIntroduction To use the ‘gold standard’ technique of scintigraphy to quantify gastric emptying (GE) as soon as practicable during an admission with diabetic ketoacidosis (DKA) and following its resolution at least 7 days later.Research design and methods Five patients with type 1 diabetes, age 29±12 years; Body Mass Index 23±3 kg/m2; hemoglobin A1c 11.3%±1.9%, were studied during an admission with DKA and following its resolution. Solid and liquid GE were measured using scintigraphy. Solid emptying was assessed via the percentage intragastric retention at 100 min and that of liquid by the 50% emptying time.Results There was no difference in either solid or liquid GE at the initial study compared with the follow-up. Median (IQR) solid retention was 47±20 versus 38%±33%, respectively; p=0.31, and time to empty 50% of liquid was 37±25 min versus 35±15 min, p=0.31, at the initial and follow-up GE study, respectively.Conclusions GE of solids and liquids is not affected by moderate DKA, inferring that earlier reintroduction of oral intake may be appropriate.https://drc.bmj.com/content/12/2/e003854.full |
| spellingShingle | Michael Horowitz Karen L Jones Christopher K Rayner Ryan J Jalleh Liza Phillips Mahesh M Umapathysivam Chinmay S Marathe Linda E Watson Michelle Bound Gastric emptying during and following resolution of moderate diabetic ketoacidosis in type 1 diabetes: a case series BMJ Open Diabetes Research & Care |
| title | Gastric emptying during and following resolution of moderate diabetic ketoacidosis in type 1 diabetes: a case series |
| title_full | Gastric emptying during and following resolution of moderate diabetic ketoacidosis in type 1 diabetes: a case series |
| title_fullStr | Gastric emptying during and following resolution of moderate diabetic ketoacidosis in type 1 diabetes: a case series |
| title_full_unstemmed | Gastric emptying during and following resolution of moderate diabetic ketoacidosis in type 1 diabetes: a case series |
| title_short | Gastric emptying during and following resolution of moderate diabetic ketoacidosis in type 1 diabetes: a case series |
| title_sort | gastric emptying during and following resolution of moderate diabetic ketoacidosis in type 1 diabetes a case series |
| url | https://drc.bmj.com/content/12/2/e003854.full |
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