Oxygen-sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradation
Abstract Magnesium (Mg) alloys are becoming increasingly important in the biomedical field as temporary bone implants. However, the biodegradation process of Mg alloys is highly complex and recent findings suggest that oxygen (O2) consumption is non-negligible. In this study, we give experimental pr...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
|
| Series: | npj Materials Degradation |
| Online Access: | https://doi.org/10.1038/s41529-022-00302-9 |
| _version_ | 1811217841601380352 |
|---|---|
| author | Berit Zeller-Plumhoff Ashwini Rahul Akkineni Heike Helmholz Dmytro Orlov Maria Mosshammer Michael Kühl Regine Willumeit-Römer Michael Gelinsky |
| author_facet | Berit Zeller-Plumhoff Ashwini Rahul Akkineni Heike Helmholz Dmytro Orlov Maria Mosshammer Michael Kühl Regine Willumeit-Römer Michael Gelinsky |
| author_sort | Berit Zeller-Plumhoff |
| collection | DOAJ |
| description | Abstract Magnesium (Mg) alloys are becoming increasingly important in the biomedical field as temporary bone implants. However, the biodegradation process of Mg alloys is highly complex and recent findings suggest that oxygen (O2) consumption is non-negligible. In this study, we give experimental proof of O2 consumption during Mg degradation under physiological conditions. Specifically, we study pure Mg, Mg–6 wt%Ag and Mg–5 wt%Gd in Hanks’ balanced salt solution and Dulbecco’s modified Eagle’s medium. We show that O2 consumption and hydrogen evolution are inversely correlated and that O2 concentrations remain below 7.5% in certain cases, which could have significant implications for bone healing. |
| first_indexed | 2024-04-12T07:00:51Z |
| format | Article |
| id | doaj.art-ddb0810fb1fb4e3dbc697c88bbe35314 |
| institution | Directory Open Access Journal |
| issn | 2397-2106 |
| language | English |
| last_indexed | 2024-04-12T07:00:51Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Materials Degradation |
| spelling | doaj.art-ddb0810fb1fb4e3dbc697c88bbe353142022-12-22T03:43:01ZengNature Portfolionpj Materials Degradation2397-21062022-11-01611810.1038/s41529-022-00302-9Oxygen-sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradationBerit Zeller-Plumhoff0Ashwini Rahul Akkineni1Heike Helmholz2Dmytro Orlov3Maria Mosshammer4Michael Kühl5Regine Willumeit-Römer6Michael Gelinsky7Institute of Metallic Biomaterials, Helmholtz-Zentrum HereonCentre for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus and Faculty of Medicine of Technische Universität DresdenInstitute of Metallic Biomaterials, Helmholtz-Zentrum HereonDivision of Materials Engineering LTH, Lund UniversityMarine Biology Section, Department of Biology, University of CopenhagenMarine Biology Section, Department of Biology, University of CopenhagenInstitute of Metallic Biomaterials, Helmholtz-Zentrum HereonCentre for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus and Faculty of Medicine of Technische Universität DresdenAbstract Magnesium (Mg) alloys are becoming increasingly important in the biomedical field as temporary bone implants. However, the biodegradation process of Mg alloys is highly complex and recent findings suggest that oxygen (O2) consumption is non-negligible. In this study, we give experimental proof of O2 consumption during Mg degradation under physiological conditions. Specifically, we study pure Mg, Mg–6 wt%Ag and Mg–5 wt%Gd in Hanks’ balanced salt solution and Dulbecco’s modified Eagle’s medium. We show that O2 consumption and hydrogen evolution are inversely correlated and that O2 concentrations remain below 7.5% in certain cases, which could have significant implications for bone healing.https://doi.org/10.1038/s41529-022-00302-9 |
| spellingShingle | Berit Zeller-Plumhoff Ashwini Rahul Akkineni Heike Helmholz Dmytro Orlov Maria Mosshammer Michael Kühl Regine Willumeit-Römer Michael Gelinsky Oxygen-sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradation npj Materials Degradation |
| title | Oxygen-sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradation |
| title_full | Oxygen-sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradation |
| title_fullStr | Oxygen-sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradation |
| title_full_unstemmed | Oxygen-sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradation |
| title_short | Oxygen-sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradation |
| title_sort | oxygen sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradation |
| url | https://doi.org/10.1038/s41529-022-00302-9 |
| work_keys_str_mv | AT beritzellerplumhoff oxygensensitivenanoparticlesrevealthespatiotemporaldynamicsofoxygenreductionduringmagnesiumimplantbiodegradation AT ashwinirahulakkineni oxygensensitivenanoparticlesrevealthespatiotemporaldynamicsofoxygenreductionduringmagnesiumimplantbiodegradation AT heikehelmholz oxygensensitivenanoparticlesrevealthespatiotemporaldynamicsofoxygenreductionduringmagnesiumimplantbiodegradation AT dmytroorlov oxygensensitivenanoparticlesrevealthespatiotemporaldynamicsofoxygenreductionduringmagnesiumimplantbiodegradation AT mariamosshammer oxygensensitivenanoparticlesrevealthespatiotemporaldynamicsofoxygenreductionduringmagnesiumimplantbiodegradation AT michaelkuhl oxygensensitivenanoparticlesrevealthespatiotemporaldynamicsofoxygenreductionduringmagnesiumimplantbiodegradation AT reginewillumeitromer oxygensensitivenanoparticlesrevealthespatiotemporaldynamicsofoxygenreductionduringmagnesiumimplantbiodegradation AT michaelgelinsky oxygensensitivenanoparticlesrevealthespatiotemporaldynamicsofoxygenreductionduringmagnesiumimplantbiodegradation |