Indigo Carmine Hemodynamic Studies to Treat Vasoplegia Induced by Compound 48/80 in a Swine Model of Anaphylaxis
Abstract Introduction: There are many reasons to believe that the nitric oxide/guanosine 3’5’ - cyclic monophosphate (or NO/cGMP) pathway on vasoplegic states is underestimated. To study indigo carmine (IC) as an alternative to methylene blue was the investigation rationale. Methods: The IC (3mg/k...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cirurgia Cardiovascular
2022-03-01
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| Series: | Brazilian Journal of Cardiovascular Surgery |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382022000100020&lng=en&tlng=en |
| _version_ | 1818252707636445184 |
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| author | Agnes Afrodite S Albuquerque Andrea Carla Celotto Christiane Becari Marelaine Prandi Jessyca M Barbosa Francisco Moreira Neto Maria Cecília Jordani Paulo Roberto B Evora |
| author_facet | Agnes Afrodite S Albuquerque Andrea Carla Celotto Christiane Becari Marelaine Prandi Jessyca M Barbosa Francisco Moreira Neto Maria Cecília Jordani Paulo Roberto B Evora |
| author_sort | Agnes Afrodite S Albuquerque |
| collection | DOAJ |
| description | Abstract Introduction: There are many reasons to believe that the nitric oxide/guanosine 3’5’ - cyclic monophosphate (or NO/cGMP) pathway on vasoplegic states is underestimated. To study indigo carmine (IC) as an alternative to methylene blue was the investigation rationale. Methods: The IC (3mg/kg intravenous infusion) study protocol included five experimental groups; 1) Control group — saline was injected at 0 and 10 minutes; 2) IC group — IC was injected at 0 and saline at 10 minutes; 3) compound 48/80 (C48/80) group — C48/80 was injected at 0 minute and saline at 10 minutes; 4) C48/80 + IC group — C48/80 was injected at 0 minute and IC at 10 minutes; and 5) IC + C48/80 group — IC was injected at 0 minute and C48/80 at 10 minutes. The studies were carried out by registering and measuring hemodynamic and blood gasometric parameters, including continuous cardiac output. Results: 1) The effects of the drugs (IC and C48/80) were more evident in the first 20 minutes of recording; 2) hypotensive responses were more pronounced in the C48/80 groups; 3) IC isolated or applied before C48/80 caused transient pulmonary hypertension; and 4) after the first 20 minutes, the pressure responses showed stability with apparent hypotension more pronounced in the C48/80 groups. Clinical observations showed significant hemodynamic instability and catastrophic anaphylactic reactions (agitation, pulmonary hypertension, severe bronchospasm, urticaria, high-intensity cyanosis, violent gastric hypersecretion, and ascites). Conclusion: A global results analysis showed differences between groups only in the first 20 minutes of the experiments. |
| first_indexed | 2024-12-12T16:28:27Z |
| format | Article |
| id | doaj.art-ddb090b49a7942398b645294a93e2962 |
| institution | Directory Open Access Journal |
| issn | 1678-9741 |
| language | English |
| last_indexed | 2024-12-12T16:28:27Z |
| publishDate | 2022-03-01 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| record_format | Article |
| series | Brazilian Journal of Cardiovascular Surgery |
| spelling | doaj.art-ddb090b49a7942398b645294a93e29622022-12-22T00:18:50ZengSociedade Brasileira de Cirurgia CardiovascularBrazilian Journal of Cardiovascular Surgery1678-97412022-03-01371202810.21470/1678-9741-2020-0622Indigo Carmine Hemodynamic Studies to Treat Vasoplegia Induced by Compound 48/80 in a Swine Model of AnaphylaxisAgnes Afrodite S AlbuquerqueAndrea Carla CelottoChristiane BecariMarelaine PrandiJessyca M BarbosaFrancisco Moreira NetoMaria Cecília JordaniPaulo Roberto B Evorahttps://orcid.org/0000-0001-9631-946XAbstract Introduction: There are many reasons to believe that the nitric oxide/guanosine 3’5’ - cyclic monophosphate (or NO/cGMP) pathway on vasoplegic states is underestimated. To study indigo carmine (IC) as an alternative to methylene blue was the investigation rationale. Methods: The IC (3mg/kg intravenous infusion) study protocol included five experimental groups; 1) Control group — saline was injected at 0 and 10 minutes; 2) IC group — IC was injected at 0 and saline at 10 minutes; 3) compound 48/80 (C48/80) group — C48/80 was injected at 0 minute and saline at 10 minutes; 4) C48/80 + IC group — C48/80 was injected at 0 minute and IC at 10 minutes; and 5) IC + C48/80 group — IC was injected at 0 minute and C48/80 at 10 minutes. The studies were carried out by registering and measuring hemodynamic and blood gasometric parameters, including continuous cardiac output. Results: 1) The effects of the drugs (IC and C48/80) were more evident in the first 20 minutes of recording; 2) hypotensive responses were more pronounced in the C48/80 groups; 3) IC isolated or applied before C48/80 caused transient pulmonary hypertension; and 4) after the first 20 minutes, the pressure responses showed stability with apparent hypotension more pronounced in the C48/80 groups. Clinical observations showed significant hemodynamic instability and catastrophic anaphylactic reactions (agitation, pulmonary hypertension, severe bronchospasm, urticaria, high-intensity cyanosis, violent gastric hypersecretion, and ascites). Conclusion: A global results analysis showed differences between groups only in the first 20 minutes of the experiments.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382022000100020&lng=en&tlng=enIndigo CarmineAnaphylaxisAnaphylactic ShockVasoplegiaNitric OxideMethylene Blue |
| spellingShingle | Agnes Afrodite S Albuquerque Andrea Carla Celotto Christiane Becari Marelaine Prandi Jessyca M Barbosa Francisco Moreira Neto Maria Cecília Jordani Paulo Roberto B Evora Indigo Carmine Hemodynamic Studies to Treat Vasoplegia Induced by Compound 48/80 in a Swine Model of Anaphylaxis Brazilian Journal of Cardiovascular Surgery Indigo Carmine Anaphylaxis Anaphylactic Shock Vasoplegia Nitric Oxide Methylene Blue |
| title | Indigo Carmine Hemodynamic Studies to Treat Vasoplegia Induced by Compound 48/80 in a Swine Model of Anaphylaxis |
| title_full | Indigo Carmine Hemodynamic Studies to Treat Vasoplegia Induced by Compound 48/80 in a Swine Model of Anaphylaxis |
| title_fullStr | Indigo Carmine Hemodynamic Studies to Treat Vasoplegia Induced by Compound 48/80 in a Swine Model of Anaphylaxis |
| title_full_unstemmed | Indigo Carmine Hemodynamic Studies to Treat Vasoplegia Induced by Compound 48/80 in a Swine Model of Anaphylaxis |
| title_short | Indigo Carmine Hemodynamic Studies to Treat Vasoplegia Induced by Compound 48/80 in a Swine Model of Anaphylaxis |
| title_sort | indigo carmine hemodynamic studies to treat vasoplegia induced by compound 48 80 in a swine model of anaphylaxis |
| topic | Indigo Carmine Anaphylaxis Anaphylactic Shock Vasoplegia Nitric Oxide Methylene Blue |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382022000100020&lng=en&tlng=en |
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