Nuciferine protects bovine hepatocytes against free fatty acid–induced oxidative damage by activating the transcription factor EB/peroxisome proliferator-activated receptor γ coactivator 1 alpha pathway

Nuciferine protects bovine hepatocytes against free fatty acid–induced oxidative damage by activating the transcription factor EB/peroxisome proliferator-activated receptor γ coactivator 1 alpha pathway

ABSTRACT: Excessive free fatty acid (FFA) oxidation and related metabolism are the major cause of oxidative stress and liver injury in dairy cows during the early postpartum period. In nonruminants, activation of transcription factor EB (TFEB) can improve cell damage and reduce the overproduction of...

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Bibliographic Details
Main Authors: Zhiyuan Fang, Xiuhuan Jiang, Shu Wang, Wenjun Tai, Qianming Jiang, Juan J. Loor, Hao Yu, Xue Hao, Meng Chen, Qi Shao, Yuxiang Song, Lin Lei, Guowen Liu, Xiliang Du, Xinwei Li
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Journal of Dairy Science
Subjects:
oxidative stress
liver injury
periparturient period
dairy cow
Online Access:http://www.sciencedirect.com/science/article/pii/S0022030223006434

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