In Vitro Analyses of the Toxicity, Immunological, and Gene Expression Effects of Cobalt-Chromium Alloy Wear Debris and Co Ions Derived from Metal-on-Metal Hip Implants
Joint replacement has proven to be an extremely successful and cost-effective means of relieving arthritic pain and improving quality of life for recipients. Wear debris-induced osteolysis is, however, a major limitation and causes orthopaedic implant aseptic loosening, and various cell types inclu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-07-01
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| Series: | Lubricants |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2075-4442/3/3/539 |
| _version_ | 1798006346991271936 |
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| author | Olga M. Posada Rothwelle J. Tate R.M. Dominic Meek M. Helen Grant |
| author_facet | Olga M. Posada Rothwelle J. Tate R.M. Dominic Meek M. Helen Grant |
| author_sort | Olga M. Posada |
| collection | DOAJ |
| description | Joint replacement has proven to be an extremely successful and cost-effective means of relieving arthritic pain and improving quality of life for recipients. Wear debris-induced osteolysis is, however, a major limitation and causes orthopaedic implant aseptic loosening, and various cell types including macrophages, monocytes, osteoblasts, and osteoclasts, are involved. During the last few years, there has been increasing concern about metal-on-metal (MoM) hip replacements regarding adverse reactions to metal debris associated with the MoM articulation. Even though MoM-bearing technology was initially aimed to extend the durability of hip replacements and to reduce the requirement for revision, they have been reported to release at least three times more cobalt and chromium ions than metal-on-polyethylene (MoP) hip replacements. As a result, the toxicity of metal particles and ions produced by bearing surfaces, both locally in the periprosthetic space and systemically, became a concern. Several investigations have been carried out to understand the mechanisms responsible for the adverse response to metal wear debris. This review aims at summarising in vitro analyses of the toxicity, immunological, and gene expression effects of cobalt ions and wear debris derived from MoM hip implants. |
| first_indexed | 2024-04-11T12:53:19Z |
| format | Article |
| id | doaj.art-ddb173a18bba4d5ea840fad59614c01d |
| institution | Directory Open Access Journal |
| issn | 2075-4442 |
| language | English |
| last_indexed | 2024-04-11T12:53:19Z |
| publishDate | 2015-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Lubricants |
| spelling | doaj.art-ddb173a18bba4d5ea840fad59614c01d2022-12-22T04:23:08ZengMDPI AGLubricants2075-44422015-07-013353956810.3390/lubricants3030539lubricants3030539In Vitro Analyses of the Toxicity, Immunological, and Gene Expression Effects of Cobalt-Chromium Alloy Wear Debris and Co Ions Derived from Metal-on-Metal Hip ImplantsOlga M. Posada0Rothwelle J. Tate1R.M. Dominic Meek2M. Helen Grant3Biomedical Engineering Department, University of Strathclyde, Wolfson Centre, Glasgow G4 0NW, UKStrathclyde Institute for Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UKDepartment of Orthopaedic Surgery, Southern General Hospital, Glasgow G11 6NT, UKBiomedical Engineering Department, University of Strathclyde, Wolfson Centre, Glasgow G4 0NW, UKJoint replacement has proven to be an extremely successful and cost-effective means of relieving arthritic pain and improving quality of life for recipients. Wear debris-induced osteolysis is, however, a major limitation and causes orthopaedic implant aseptic loosening, and various cell types including macrophages, monocytes, osteoblasts, and osteoclasts, are involved. During the last few years, there has been increasing concern about metal-on-metal (MoM) hip replacements regarding adverse reactions to metal debris associated with the MoM articulation. Even though MoM-bearing technology was initially aimed to extend the durability of hip replacements and to reduce the requirement for revision, they have been reported to release at least three times more cobalt and chromium ions than metal-on-polyethylene (MoP) hip replacements. As a result, the toxicity of metal particles and ions produced by bearing surfaces, both locally in the periprosthetic space and systemically, became a concern. Several investigations have been carried out to understand the mechanisms responsible for the adverse response to metal wear debris. This review aims at summarising in vitro analyses of the toxicity, immunological, and gene expression effects of cobalt ions and wear debris derived from MoM hip implants.http://www.mdpi.com/2075-4442/3/3/539wear debriscobaltmetal-on-metalhip implants |
| spellingShingle | Olga M. Posada Rothwelle J. Tate R.M. Dominic Meek M. Helen Grant In Vitro Analyses of the Toxicity, Immunological, and Gene Expression Effects of Cobalt-Chromium Alloy Wear Debris and Co Ions Derived from Metal-on-Metal Hip Implants Lubricants wear debris cobalt metal-on-metal hip implants |
| title | In Vitro Analyses of the Toxicity, Immunological, and Gene Expression Effects of Cobalt-Chromium Alloy Wear Debris and Co Ions Derived from Metal-on-Metal Hip Implants |
| title_full | In Vitro Analyses of the Toxicity, Immunological, and Gene Expression Effects of Cobalt-Chromium Alloy Wear Debris and Co Ions Derived from Metal-on-Metal Hip Implants |
| title_fullStr | In Vitro Analyses of the Toxicity, Immunological, and Gene Expression Effects of Cobalt-Chromium Alloy Wear Debris and Co Ions Derived from Metal-on-Metal Hip Implants |
| title_full_unstemmed | In Vitro Analyses of the Toxicity, Immunological, and Gene Expression Effects of Cobalt-Chromium Alloy Wear Debris and Co Ions Derived from Metal-on-Metal Hip Implants |
| title_short | In Vitro Analyses of the Toxicity, Immunological, and Gene Expression Effects of Cobalt-Chromium Alloy Wear Debris and Co Ions Derived from Metal-on-Metal Hip Implants |
| title_sort | in vitro analyses of the toxicity immunological and gene expression effects of cobalt chromium alloy wear debris and co ions derived from metal on metal hip implants |
| topic | wear debris cobalt metal-on-metal hip implants |
| url | http://www.mdpi.com/2075-4442/3/3/539 |
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