Microphysiologic Human Tissue Constructs Reproduce Autologous Age-Specific BCG and HBV Primary Immunization in vitro

Microphysiologic Human Tissue Constructs Reproduce Autologous Age-Specific BCG and HBV Primary Immunization in vitro

Current vaccine development disregards human immune ontogeny, relying on animal models to select vaccine candidates targeting human infants, who are at greatest risk of infection worldwide, and receive the largest number of vaccines. To help accelerate and de-risk development of early-life effective...

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Bibliographic Details
Main Authors: Guzman Sanchez-Schmitz, Chad R. Stevens, Ian A. Bettencourt, Peter J. Flynn, Klaus Schmitz-Abe, Gil Metser, David Hamm, Kristoffer J. Jensen, Christine Benn, Ofer Levy
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
microphysiology
model
newborn
vaccine
immunization
autologous
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02634/full

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