Successful use of gentamycin as an antibiotic prophylaxis regimen to reduce the rate of healthcare-associated infections after renal transplantation
At our institution, we observed an increase in the incidence of healthcare-associated infections (HAI) due to Gram-negative bacilli, including three cases of carbapenem-resistant Klebsiella pneumoniae, among patients who underwent renal transplantation. In addition to strengthening infection control...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-04-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200021 |
| _version_ | 1811223026724765696 |
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| author | Cely S. Abboud Maria Daniela Bergamasco Ercilia Evangelista de Sousa Eliana de Cássia Zandonadi Doralice Cortez |
| author_facet | Cely S. Abboud Maria Daniela Bergamasco Ercilia Evangelista de Sousa Eliana de Cássia Zandonadi Doralice Cortez |
| author_sort | Cely S. Abboud |
| collection | DOAJ |
| description | At our institution, we observed an increase in the incidence of healthcare-associated infections (HAI) due to Gram-negative bacilli, including three cases of carbapenem-resistant Klebsiella pneumoniae, among patients who underwent renal transplantation. In addition to strengthening infection control measures, we chose to add gentamycin to the antibiotic prophylaxis regimen of patients undergoing renal transplantation. We assessed the number of HAI occurring within 30 days of renal transplantation during two time periods: (1) the preintervention period, between September 2009 and June 2010, and (2) the post-intervention period, between July 2010 and April 2011. The intervention consisted of the addition of gentamycin to the surgical antibiotic prophylaxis regimen. The percentage of patients with HAIs was 31% lower during the post-intervention period (p = 0.03), with the greatest reductions observed for urinary tract infections (p = 0.024). Carbapenem-resistant K. pneumoniae was not isolated during this period. The investigated patients did not exhibit worsening renal function. Further studies are needed to assess antibiotic prophylaxis in renal transplantation patients at institutions where there is a high prevalence of multidrug-resistant Gram-negative bacteria. |
| first_indexed | 2024-04-12T08:25:53Z |
| format | Article |
| id | doaj.art-ddb268a5e46c4f37b5534c771e68ceb6 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 1678-4391 |
| language | English |
| last_indexed | 2024-04-12T08:25:53Z |
| publishDate | 2013-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-ddb268a5e46c4f37b5534c771e68ceb62022-12-22T03:40:25ZengElsevierBrazilian Journal of Infectious Diseases1413-86701678-43912013-04-01172254255Successful use of gentamycin as an antibiotic prophylaxis regimen to reduce the rate of healthcare-associated infections after renal transplantationCely S. AbboudMaria Daniela BergamascoErcilia Evangelista de SousaEliana de Cássia ZandonadiDoralice CortezAt our institution, we observed an increase in the incidence of healthcare-associated infections (HAI) due to Gram-negative bacilli, including three cases of carbapenem-resistant Klebsiella pneumoniae, among patients who underwent renal transplantation. In addition to strengthening infection control measures, we chose to add gentamycin to the antibiotic prophylaxis regimen of patients undergoing renal transplantation. We assessed the number of HAI occurring within 30 days of renal transplantation during two time periods: (1) the preintervention period, between September 2009 and June 2010, and (2) the post-intervention period, between July 2010 and April 2011. The intervention consisted of the addition of gentamycin to the surgical antibiotic prophylaxis regimen. The percentage of patients with HAIs was 31% lower during the post-intervention period (p = 0.03), with the greatest reductions observed for urinary tract infections (p = 0.024). Carbapenem-resistant K. pneumoniae was not isolated during this period. The investigated patients did not exhibit worsening renal function. Further studies are needed to assess antibiotic prophylaxis in renal transplantation patients at institutions where there is a high prevalence of multidrug-resistant Gram-negative bacteria.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200021Renal transplantationAntibiotic prophylaxisGentamycinHealth-care associated infections |
| spellingShingle | Cely S. Abboud Maria Daniela Bergamasco Ercilia Evangelista de Sousa Eliana de Cássia Zandonadi Doralice Cortez Successful use of gentamycin as an antibiotic prophylaxis regimen to reduce the rate of healthcare-associated infections after renal transplantation Brazilian Journal of Infectious Diseases Renal transplantation Antibiotic prophylaxis Gentamycin Health-care associated infections |
| title | Successful use of gentamycin as an antibiotic prophylaxis regimen to reduce the rate of healthcare-associated infections after renal transplantation |
| title_full | Successful use of gentamycin as an antibiotic prophylaxis regimen to reduce the rate of healthcare-associated infections after renal transplantation |
| title_fullStr | Successful use of gentamycin as an antibiotic prophylaxis regimen to reduce the rate of healthcare-associated infections after renal transplantation |
| title_full_unstemmed | Successful use of gentamycin as an antibiotic prophylaxis regimen to reduce the rate of healthcare-associated infections after renal transplantation |
| title_short | Successful use of gentamycin as an antibiotic prophylaxis regimen to reduce the rate of healthcare-associated infections after renal transplantation |
| title_sort | successful use of gentamycin as an antibiotic prophylaxis regimen to reduce the rate of healthcare associated infections after renal transplantation |
| topic | Renal transplantation Antibiotic prophylaxis Gentamycin Health-care associated infections |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200021 |
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