The mechanism and therapeutic strategies for neovascular glaucoma secondary to diabetic retinopathy
Neovascular glaucoma (NVG) is a devastating secondary glaucoma characterized by the appearance of neovascular over the iris and the proliferation of fibrovascular tissue in the anterior chamber angle. Proliferative diabetic retinopathy (PDR) is one of the leading causes of NVG. Currently increasing...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1102361/full |
| _version_ | 1828056195618832384 |
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| author | Yizhen Tang Yizhen Tang Yan Shi Yan Shi Zhigang Fan Zhigang Fan |
| author_facet | Yizhen Tang Yizhen Tang Yan Shi Yan Shi Zhigang Fan Zhigang Fan |
| author_sort | Yizhen Tang |
| collection | DOAJ |
| description | Neovascular glaucoma (NVG) is a devastating secondary glaucoma characterized by the appearance of neovascular over the iris and the proliferation of fibrovascular tissue in the anterior chamber angle. Proliferative diabetic retinopathy (PDR) is one of the leading causes of NVG. Currently increasing diabetes population drive the prevalence rate of NVG into a fast-rising lane. The pathogenesis underlying NVG makes it refractory to routine management for other types of glaucoma in clinical practice. The combination of panretinal photocoagulation (PRP), anti-vascular endothelial growth factor (VEGF) injections, anti-glaucoma drugs, surgical intervention as well as blood glucose control is needed. Early diagnosis and aggressive treatment in time are crucial in halting the neovascularization process and preserving vision. This review provides an overview of NVG secondary to diabetic retinopathy (DR), including the epidemiology, pathogenesis and management, so as to provide a better understanding as well as potential therapeutic strategies for future treatment. |
| first_indexed | 2024-04-10T20:51:48Z |
| format | Article |
| id | doaj.art-ddb3cc1888004f62b91850e4dbea9de3 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T20:51:48Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ddb3cc1888004f62b91850e4dbea9de32023-01-23T12:16:54ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-01-011410.3389/fendo.2023.11023611102361The mechanism and therapeutic strategies for neovascular glaucoma secondary to diabetic retinopathyYizhen Tang0Yizhen Tang1Yan Shi2Yan Shi3Zhigang Fan4Zhigang Fan5Beijing Ophthalmology and Visual Sciences Key Laboratory, Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaInstitute of Ophthalmology, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University, Beijing, ChinaBeijing Ophthalmology and Visual Sciences Key Laboratory, Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaInstitute of Ophthalmology, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University, Beijing, ChinaBeijing Ophthalmology and Visual Sciences Key Laboratory, Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaInstitute of Ophthalmology, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University, Beijing, ChinaNeovascular glaucoma (NVG) is a devastating secondary glaucoma characterized by the appearance of neovascular over the iris and the proliferation of fibrovascular tissue in the anterior chamber angle. Proliferative diabetic retinopathy (PDR) is one of the leading causes of NVG. Currently increasing diabetes population drive the prevalence rate of NVG into a fast-rising lane. The pathogenesis underlying NVG makes it refractory to routine management for other types of glaucoma in clinical practice. The combination of panretinal photocoagulation (PRP), anti-vascular endothelial growth factor (VEGF) injections, anti-glaucoma drugs, surgical intervention as well as blood glucose control is needed. Early diagnosis and aggressive treatment in time are crucial in halting the neovascularization process and preserving vision. This review provides an overview of NVG secondary to diabetic retinopathy (DR), including the epidemiology, pathogenesis and management, so as to provide a better understanding as well as potential therapeutic strategies for future treatment.https://www.frontiersin.org/articles/10.3389/fendo.2023.1102361/fullneovascular glaucomadiabetic retinopathypathogenesisepidemiologymanagement |
| spellingShingle | Yizhen Tang Yizhen Tang Yan Shi Yan Shi Zhigang Fan Zhigang Fan The mechanism and therapeutic strategies for neovascular glaucoma secondary to diabetic retinopathy Frontiers in Endocrinology neovascular glaucoma diabetic retinopathy pathogenesis epidemiology management |
| title | The mechanism and therapeutic strategies for neovascular glaucoma secondary to diabetic retinopathy |
| title_full | The mechanism and therapeutic strategies for neovascular glaucoma secondary to diabetic retinopathy |
| title_fullStr | The mechanism and therapeutic strategies for neovascular glaucoma secondary to diabetic retinopathy |
| title_full_unstemmed | The mechanism and therapeutic strategies for neovascular glaucoma secondary to diabetic retinopathy |
| title_short | The mechanism and therapeutic strategies for neovascular glaucoma secondary to diabetic retinopathy |
| title_sort | mechanism and therapeutic strategies for neovascular glaucoma secondary to diabetic retinopathy |
| topic | neovascular glaucoma diabetic retinopathy pathogenesis epidemiology management |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1102361/full |
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