Genetic Aspects of Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is the most commonly diagnosed hepatopathy. There is an increase in the incidence of NAFLD in the structure of liver diseases in children and adolescents, which is directly related to the increasing prevalence of obesity. The spectrum of liver tissue changes...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2019-01-01
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| Series: | Вопросы современной педиатрии |
| Subjects: | |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/1975 |
| _version_ | 1797702245499797504 |
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| author | Pavel O. Bogomolov Kseniya Yu. Kokina Aleksander Yu. Mayorov Ekaterina E. Mishina |
| author_facet | Pavel O. Bogomolov Kseniya Yu. Kokina Aleksander Yu. Mayorov Ekaterina E. Mishina |
| author_sort | Pavel O. Bogomolov |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is the most commonly diagnosed hepatopathy. There is an increase in the incidence of NAFLD in the structure of liver diseases in children and adolescents, which is directly related to the increasing prevalence of obesity. The spectrum of liver tissue changes in NAFLD ranges from benign hepatocellular steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis of the liver, and hepatocellular carcinoma. With the increasing prevalence of NAFLD in children, we can expect an increase in the incidence of adverse outcomes among people of working age. The key problem for NAFLD is the prediction of disease outcomes. In epidemiological and genetic studies, the relationship between the morphological stage of NAFLD and hereditary factors is shown. Currently, there are three genes associated with NAFLD (PNPLA3, TM6SF2, and GCKR), which, together with the genes responsible for insulin resistance, lipid deposition, inflammation and fibrogenesis in hepatocytes, determine the phenotype of fatty liver disease. The article considers the modern understanding of the issues of genetics, development of liver steatosis and progression of NASH. It is expected that this knowledge can transform our risk stratification strategies in patients with NAFLD and help identify new therapeutic goals. |
| first_indexed | 2024-03-12T04:48:22Z |
| format | Article |
| id | doaj.art-ddb3d5f49ca94b46af367624ee18177e |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2024-03-12T04:48:22Z |
| publishDate | 2019-01-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-ddb3d5f49ca94b46af367624ee18177e2023-09-03T09:26:50Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352019-01-0117644244810.15690/vsp.v17i6.19741788Genetic Aspects of Non-Alcoholic Fatty Liver DiseasePavel O. Bogomolov0Kseniya Yu. Kokina1Aleksander Yu. Mayorov2Ekaterina E. Mishina3Московский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоМосковский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоНациональный медицинский исследовательский центр эндокринологииНациональный медицинский исследовательский центр эндокринологииNon-alcoholic fatty liver disease (NAFLD) is the most commonly diagnosed hepatopathy. There is an increase in the incidence of NAFLD in the structure of liver diseases in children and adolescents, which is directly related to the increasing prevalence of obesity. The spectrum of liver tissue changes in NAFLD ranges from benign hepatocellular steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis of the liver, and hepatocellular carcinoma. With the increasing prevalence of NAFLD in children, we can expect an increase in the incidence of adverse outcomes among people of working age. The key problem for NAFLD is the prediction of disease outcomes. In epidemiological and genetic studies, the relationship between the morphological stage of NAFLD and hereditary factors is shown. Currently, there are three genes associated with NAFLD (PNPLA3, TM6SF2, and GCKR), which, together with the genes responsible for insulin resistance, lipid deposition, inflammation and fibrogenesis in hepatocytes, determine the phenotype of fatty liver disease. The article considers the modern understanding of the issues of genetics, development of liver steatosis and progression of NASH. It is expected that this knowledge can transform our risk stratification strategies in patients with NAFLD and help identify new therapeutic goals.https://vsp.spr-journal.ru/jour/article/view/1975неалкогольная жировая болезнь печенинеалкогольный стеатогепатитгенотипированиеген pnpla3ген mboat7ген tm6sf2ген gckr |
| spellingShingle | Pavel O. Bogomolov Kseniya Yu. Kokina Aleksander Yu. Mayorov Ekaterina E. Mishina Genetic Aspects of Non-Alcoholic Fatty Liver Disease Вопросы современной педиатрии неалкогольная жировая болезнь печени неалкогольный стеатогепатит генотипирование ген pnpla3 ген mboat7 ген tm6sf2 ген gckr |
| title | Genetic Aspects of Non-Alcoholic Fatty Liver Disease |
| title_full | Genetic Aspects of Non-Alcoholic Fatty Liver Disease |
| title_fullStr | Genetic Aspects of Non-Alcoholic Fatty Liver Disease |
| title_full_unstemmed | Genetic Aspects of Non-Alcoholic Fatty Liver Disease |
| title_short | Genetic Aspects of Non-Alcoholic Fatty Liver Disease |
| title_sort | genetic aspects of non alcoholic fatty liver disease |
| topic | неалкогольная жировая болезнь печени неалкогольный стеатогепатит генотипирование ген pnpla3 ген mboat7 ген tm6sf2 ген gckr |
| url | https://vsp.spr-journal.ru/jour/article/view/1975 |
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