Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe?
Regulated in Development and DNA Damage Response 1 (REDD1)/DNA Damage-Induced Transcript 4 (DDIT4) is an immediate early response gene activated by different stress conditions, including growth factor depletion, hypoxia, DNA damage, and stress hormones, i.e., glucocorticoids. The most known function...
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| author | Ekaterina M. Zhidkova Evgeniya S. Lylova Diana D. Grigoreva Kirill I. Kirsanov Alena V. Osipova Evgeny P. Kulikov Sergey A. Mertsalov Gennady A. Belitsky Irina Budunova Marianna G. Yakubovskaya Ekaterina A. Lesovaya |
| author_facet | Ekaterina M. Zhidkova Evgeniya S. Lylova Diana D. Grigoreva Kirill I. Kirsanov Alena V. Osipova Evgeny P. Kulikov Sergey A. Mertsalov Gennady A. Belitsky Irina Budunova Marianna G. Yakubovskaya Ekaterina A. Lesovaya |
| author_sort | Ekaterina M. Zhidkova |
| collection | DOAJ |
| description | Regulated in Development and DNA Damage Response 1 (REDD1)/DNA Damage-Induced Transcript 4 (DDIT4) is an immediate early response gene activated by different stress conditions, including growth factor depletion, hypoxia, DNA damage, and stress hormones, i.e., glucocorticoids. The most known functions of REDD1 are the inhibition of proliferative signaling and the regulation of metabolism via the repression of the central regulator of these processes, the mammalian target of rapamycin (mTOR). The involvement of REDD1 in cell growth, apoptosis, metabolism, and oxidative stress implies its role in various pathological conditions, including cancer and inflammatory diseases. Recently, REDD1 was identified as one of the central genes mechanistically involved in undesirable atrophic effects induced by chronic topical and systemic glucocorticoids widely used for the treatment of blood cancer and inflammatory diseases. In this review, we discuss the role of REDD1 in the regulation of cell signaling and processes in normal and cancer cells, its involvement in the pathogenesis of different diseases, and the approach to safer glucocorticoid receptor (GR)-targeted therapies via a combination of glucocorticoids and REDD1 inhibitors to decrease the adverse atrophogenic effects of these steroids. |
| first_indexed | 2024-03-10T01:46:37Z |
| format | Article |
| id | doaj.art-ddb441607d554eeda42fdb13e5f4fbbb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:46:37Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ddb441607d554eeda42fdb13e5f4fbbb2023-11-23T13:15:07ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012317968610.3390/ijms23179686Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe?Ekaterina M. Zhidkova0Evgeniya S. Lylova1Diana D. Grigoreva2Kirill I. Kirsanov3Alena V. Osipova4Evgeny P. Kulikov5Sergey A. Mertsalov6Gennady A. Belitsky7Irina Budunova8Marianna G. Yakubovskaya9Ekaterina A. Lesovaya10Department of Chemical Carcinogenesis, N.N. Blokhin NMRCO, 115478 Moscow, RussiaDepartment of Chemical Carcinogenesis, N.N. Blokhin NMRCO, 115478 Moscow, RussiaDepartment of Chemical Carcinogenesis, N.N. Blokhin NMRCO, 115478 Moscow, RussiaDepartment of Chemical Carcinogenesis, N.N. Blokhin NMRCO, 115478 Moscow, RussiaDepartment of Chemical Carcinogenesis, N.N. Blokhin NMRCO, 115478 Moscow, RussiaFaculty of Oncology, I.P. Pavlov Ryazan State Medical University, 390026 Ryazan, RussiaFaculty of Oncology, I.P. Pavlov Ryazan State Medical University, 390026 Ryazan, RussiaDepartment of Chemical Carcinogenesis, N.N. Blokhin NMRCO, 115478 Moscow, RussiaDepartment of Dermatology, Northwestern University, Chicago, IL 60611, USADepartment of Chemical Carcinogenesis, N.N. Blokhin NMRCO, 115478 Moscow, RussiaDepartment of Chemical Carcinogenesis, N.N. Blokhin NMRCO, 115478 Moscow, RussiaRegulated in Development and DNA Damage Response 1 (REDD1)/DNA Damage-Induced Transcript 4 (DDIT4) is an immediate early response gene activated by different stress conditions, including growth factor depletion, hypoxia, DNA damage, and stress hormones, i.e., glucocorticoids. The most known functions of REDD1 are the inhibition of proliferative signaling and the regulation of metabolism via the repression of the central regulator of these processes, the mammalian target of rapamycin (mTOR). The involvement of REDD1 in cell growth, apoptosis, metabolism, and oxidative stress implies its role in various pathological conditions, including cancer and inflammatory diseases. Recently, REDD1 was identified as one of the central genes mechanistically involved in undesirable atrophic effects induced by chronic topical and systemic glucocorticoids widely used for the treatment of blood cancer and inflammatory diseases. In this review, we discuss the role of REDD1 in the regulation of cell signaling and processes in normal and cancer cells, its involvement in the pathogenesis of different diseases, and the approach to safer glucocorticoid receptor (GR)-targeted therapies via a combination of glucocorticoids and REDD1 inhibitors to decrease the adverse atrophogenic effects of these steroids.https://www.mdpi.com/1422-0067/23/17/9686REDD1mTORmetabolismglucocorticoidscancerinflammation |
| spellingShingle | Ekaterina M. Zhidkova Evgeniya S. Lylova Diana D. Grigoreva Kirill I. Kirsanov Alena V. Osipova Evgeny P. Kulikov Sergey A. Mertsalov Gennady A. Belitsky Irina Budunova Marianna G. Yakubovskaya Ekaterina A. Lesovaya Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe? International Journal of Molecular Sciences REDD1 mTOR metabolism glucocorticoids cancer inflammation |
| title | Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe? |
| title_full | Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe? |
| title_fullStr | Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe? |
| title_full_unstemmed | Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe? |
| title_short | Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe? |
| title_sort | nutritional sensor redd1 in cancer and inflammation friend or foe |
| topic | REDD1 mTOR metabolism glucocorticoids cancer inflammation |
| url | https://www.mdpi.com/1422-0067/23/17/9686 |
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