The Habenula in the Link Between ADHD and Mood Disorder
Attention-deficit/hyperactivity disorder (ADHD) is a childhood-onset, neurodevelopmental disorder, whereas major depressive disorder (MDD) is a mood disorder that typically emerges in adulthood. Accumulating evidence suggests that these seemingly unrelated psychiatric disorders, whose symptoms even...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-06-01
|
| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.699691/full |
| _version_ | 1818863188460961792 |
|---|---|
| author | Young-A Lee Yukiori Goto |
| author_facet | Young-A Lee Yukiori Goto |
| author_sort | Young-A Lee |
| collection | DOAJ |
| description | Attention-deficit/hyperactivity disorder (ADHD) is a childhood-onset, neurodevelopmental disorder, whereas major depressive disorder (MDD) is a mood disorder that typically emerges in adulthood. Accumulating evidence suggests that these seemingly unrelated psychiatric disorders, whose symptoms even appear antithetical [e.g., psychomotor retardation in depression vs. hyperactivity (psychomotor acceleration) in ADHD], are in fact associated with each other. Thus, individuals with ADHD exhibit high comorbidity with MDD later in life. Moreover, genetic studies have shown substantial overlaps of susceptibility genes between ADHD and MDD. Here, we propose a novel and testable hypothesis that the habenula, the epithalamic brain region important for the regulation of monoamine transmission, may be involved in both ADHD and MDD. The hypothesis suggests that an initially hypoactive habenula during childhood in individuals with ADHD may undergo compensatory changes during development, priming the habenula to be hyperactive in response to stress exposure and thereby increasing vulnerability to MDD in adulthood. Moreover, we propose a new perspective on habenular deficits in psychiatric disorders that consider the habenula a neural substrate that could explain multiple psychiatric disorders. |
| first_indexed | 2024-12-19T10:11:47Z |
| format | Article |
| id | doaj.art-ddb5c0ae4e374b13b2fdc9e160e54ac9 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-19T10:11:47Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-ddb5c0ae4e374b13b2fdc9e160e54ac92022-12-21T20:26:21ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532021-06-011510.3389/fnbeh.2021.699691699691The Habenula in the Link Between ADHD and Mood DisorderYoung-A Lee0Yukiori Goto1Department of Food Science and Nutrition, Daegu Catholic University, Gyeongsan, South KoreaPrimate Research Institute, Kyoto University, Inuyama, JapanAttention-deficit/hyperactivity disorder (ADHD) is a childhood-onset, neurodevelopmental disorder, whereas major depressive disorder (MDD) is a mood disorder that typically emerges in adulthood. Accumulating evidence suggests that these seemingly unrelated psychiatric disorders, whose symptoms even appear antithetical [e.g., psychomotor retardation in depression vs. hyperactivity (psychomotor acceleration) in ADHD], are in fact associated with each other. Thus, individuals with ADHD exhibit high comorbidity with MDD later in life. Moreover, genetic studies have shown substantial overlaps of susceptibility genes between ADHD and MDD. Here, we propose a novel and testable hypothesis that the habenula, the epithalamic brain region important for the regulation of monoamine transmission, may be involved in both ADHD and MDD. The hypothesis suggests that an initially hypoactive habenula during childhood in individuals with ADHD may undergo compensatory changes during development, priming the habenula to be hyperactive in response to stress exposure and thereby increasing vulnerability to MDD in adulthood. Moreover, we propose a new perspective on habenular deficits in psychiatric disorders that consider the habenula a neural substrate that could explain multiple psychiatric disorders.https://www.frontiersin.org/articles/10.3389/fnbeh.2021.699691/fullneurodevelopmental disorderdepressionanimal modeldopamineserotoninp-factor |
| spellingShingle | Young-A Lee Yukiori Goto The Habenula in the Link Between ADHD and Mood Disorder Frontiers in Behavioral Neuroscience neurodevelopmental disorder depression animal model dopamine serotonin p-factor |
| title | The Habenula in the Link Between ADHD and Mood Disorder |
| title_full | The Habenula in the Link Between ADHD and Mood Disorder |
| title_fullStr | The Habenula in the Link Between ADHD and Mood Disorder |
| title_full_unstemmed | The Habenula in the Link Between ADHD and Mood Disorder |
| title_short | The Habenula in the Link Between ADHD and Mood Disorder |
| title_sort | habenula in the link between adhd and mood disorder |
| topic | neurodevelopmental disorder depression animal model dopamine serotonin p-factor |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.699691/full |
| work_keys_str_mv | AT youngalee thehabenulainthelinkbetweenadhdandmooddisorder AT yukiorigoto thehabenulainthelinkbetweenadhdandmooddisorder AT youngalee habenulainthelinkbetweenadhdandmooddisorder AT yukiorigoto habenulainthelinkbetweenadhdandmooddisorder |