Consuming artificial sweeteners may alter the structure and function of duodenal microbial communities
Summary: Studies using stool samples suggest that non-sugar sweetener (NSS) consumption affects gut microbiome composition. However, stool does not represent the entire gut. We analyzed the duodenal luminal microbiome in subjects consuming non-aspartame non-sugar sweeteners (NANS, N = 35), aspartame...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422302607X |
| _version_ | 1827582031273394176 |
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| author | Ava Hosseini Gillian M. Barlow Gabriela Leite Mohamad Rashid Gonzalo Parodi Jiajing Wang Walter Morales Stacy Weitsman Ali Rezaie Mark Pimentel Ruchi Mathur |
| author_facet | Ava Hosseini Gillian M. Barlow Gabriela Leite Mohamad Rashid Gonzalo Parodi Jiajing Wang Walter Morales Stacy Weitsman Ali Rezaie Mark Pimentel Ruchi Mathur |
| author_sort | Ava Hosseini |
| collection | DOAJ |
| description | Summary: Studies using stool samples suggest that non-sugar sweetener (NSS) consumption affects gut microbiome composition. However, stool does not represent the entire gut. We analyzed the duodenal luminal microbiome in subjects consuming non-aspartame non-sugar sweeteners (NANS, N = 35), aspartame only (ASP, N = 9), and controls (CON, N = 55) and the stool microbiome in a subset (N = 40). Duodenal alpha diversity was decreased in NANS vs. CON. Duodenal relative abundance (RA) of Escherichia, Klebsiella, and Salmonella (all phylum Proteobacteria) was lower in both NANS and ASP vs. CON, whereas stool RA of Escherichia, Klebsiella, and Salmonella was increased in both NANS and ASP vs. CON. Predicted duodenal microbial metabolic pathways altered in NANS vs. CON included polysaccharides biosynthesis and D-galactose degradation, whereas cylindrospermopsin biosynthesis was significantly enriched in ASP vs. CON. These findings suggest that consuming non-sugar sweeteners may significantly alter microbiome composition and function in the metabolically active small bowel, with different alterations seen in stool. |
| first_indexed | 2024-03-08T22:45:42Z |
| format | Article |
| id | doaj.art-ddb6401b4b9e4111b4cfc59b337c86c6 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T22:45:42Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-ddb6401b4b9e4111b4cfc59b337c86c62023-12-17T06:41:06ZengElsevieriScience2589-00422023-12-012612108530Consuming artificial sweeteners may alter the structure and function of duodenal microbial communitiesAva Hosseini0Gillian M. Barlow1Gabriela Leite2Mohamad Rashid3Gonzalo Parodi4Jiajing Wang5Walter Morales6Stacy Weitsman7Ali Rezaie8Mark Pimentel9Ruchi Mathur10Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USAMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USAMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USAMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USAMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USAMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USAMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USAMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USAMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai, Los Angeles, CA, USAMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai, Los Angeles, CA, USAMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai, Los Angeles, CA, USA; Corresponding authorSummary: Studies using stool samples suggest that non-sugar sweetener (NSS) consumption affects gut microbiome composition. However, stool does not represent the entire gut. We analyzed the duodenal luminal microbiome in subjects consuming non-aspartame non-sugar sweeteners (NANS, N = 35), aspartame only (ASP, N = 9), and controls (CON, N = 55) and the stool microbiome in a subset (N = 40). Duodenal alpha diversity was decreased in NANS vs. CON. Duodenal relative abundance (RA) of Escherichia, Klebsiella, and Salmonella (all phylum Proteobacteria) was lower in both NANS and ASP vs. CON, whereas stool RA of Escherichia, Klebsiella, and Salmonella was increased in both NANS and ASP vs. CON. Predicted duodenal microbial metabolic pathways altered in NANS vs. CON included polysaccharides biosynthesis and D-galactose degradation, whereas cylindrospermopsin biosynthesis was significantly enriched in ASP vs. CON. These findings suggest that consuming non-sugar sweeteners may significantly alter microbiome composition and function in the metabolically active small bowel, with different alterations seen in stool.http://www.sciencedirect.com/science/article/pii/S258900422302607XHealth sciencesMicrobiome |
| spellingShingle | Ava Hosseini Gillian M. Barlow Gabriela Leite Mohamad Rashid Gonzalo Parodi Jiajing Wang Walter Morales Stacy Weitsman Ali Rezaie Mark Pimentel Ruchi Mathur Consuming artificial sweeteners may alter the structure and function of duodenal microbial communities iScience Health sciences Microbiome |
| title | Consuming artificial sweeteners may alter the structure and function of duodenal microbial communities |
| title_full | Consuming artificial sweeteners may alter the structure and function of duodenal microbial communities |
| title_fullStr | Consuming artificial sweeteners may alter the structure and function of duodenal microbial communities |
| title_full_unstemmed | Consuming artificial sweeteners may alter the structure and function of duodenal microbial communities |
| title_short | Consuming artificial sweeteners may alter the structure and function of duodenal microbial communities |
| title_sort | consuming artificial sweeteners may alter the structure and function of duodenal microbial communities |
| topic | Health sciences Microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S258900422302607X |
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