TRP Channels Interactome in Pancreatic Ductal Adenocarcinoma: A Potential Therapeutic Target
Integral membrane proteins, known as Transient Receptor Potential (TRP), channels are cellular sensors for various physical and chemical stimuli in the nervous system, respiratory airways, colon, pancreas, bladder, skin, cardiovascular system, and eyes. TRP channels with nine subfamilies are classif...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Medical Sciences Forum |
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| Online Access: | https://www.mdpi.com/2673-9992/21/1/9 |
| _version_ | 1797379880045772800 |
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| author | Ahmad Taha Khalaf Yuanyuan Wei Samiah Yasmin Abdul Kadir Jamaludin Zainol Zahraa Oglah |
| author_facet | Ahmad Taha Khalaf Yuanyuan Wei Samiah Yasmin Abdul Kadir Jamaludin Zainol Zahraa Oglah |
| author_sort | Ahmad Taha Khalaf |
| collection | DOAJ |
| description | Integral membrane proteins, known as Transient Receptor Potential (TRP), channels are cellular sensors for various physical and chemical stimuli in the nervous system, respiratory airways, colon, pancreas, bladder, skin, cardiovascular system, and eyes. TRP channels with nine subfamilies are classified by sequence similarity, resulting in this superfamily’s tremendous physiological functional diversity. Pancreatic Ductal Adenocarcinoma (PDAC) is the most common and aggressive form of pancreatic cancer. Moreover, the development of effective treatment methods for pancreatic cancer has been hindered by the lack of understanding of the pathogenesis, partly due to the difficulty in studying human tissue samples. However, scientific research on this topic has witnessed steady development in the past few years in understanding the molecular mechanisms that underlie TRP channel disturbance. This brief review summarizes current knowledge of the molecular role of TRP channels in the development and progression of pancreatic ductal carcinoma to identify potential therapeutic interventions. |
| first_indexed | 2024-03-08T20:29:26Z |
| format | Article |
| id | doaj.art-ddb7b55dc8ef42efa2b090fd996ad653 |
| institution | Directory Open Access Journal |
| issn | 2673-9992 |
| language | English |
| last_indexed | 2024-03-08T20:29:26Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences Forum |
| spelling | doaj.art-ddb7b55dc8ef42efa2b090fd996ad6532023-12-22T14:28:39ZengMDPI AGMedical Sciences Forum2673-99922023-03-01211910.3390/ECB2023-14133TRP Channels Interactome in Pancreatic Ductal Adenocarcinoma: A Potential Therapeutic TargetAhmad Taha Khalaf0Yuanyuan Wei1Samiah Yasmin Abdul Kadir2Jamaludin Zainol3Zahraa Oglah4Basic Medical College, Chengdu University, Chengdu 610106, ChinaBasic Medical College, Chengdu University, Chengdu 610106, ChinaFaculty of Medicine, Widad University College, BIM Point, Bandar Indera Mahkota, Kuantan 25200, MalaysiaFaculty of Medicine, Widad University College, BIM Point, Bandar Indera Mahkota, Kuantan 25200, MalaysiaSchool of Science, Auckland University of Technology (AUT), 55 Wellesley Street, Auckland 1010, New ZealandIntegral membrane proteins, known as Transient Receptor Potential (TRP), channels are cellular sensors for various physical and chemical stimuli in the nervous system, respiratory airways, colon, pancreas, bladder, skin, cardiovascular system, and eyes. TRP channels with nine subfamilies are classified by sequence similarity, resulting in this superfamily’s tremendous physiological functional diversity. Pancreatic Ductal Adenocarcinoma (PDAC) is the most common and aggressive form of pancreatic cancer. Moreover, the development of effective treatment methods for pancreatic cancer has been hindered by the lack of understanding of the pathogenesis, partly due to the difficulty in studying human tissue samples. However, scientific research on this topic has witnessed steady development in the past few years in understanding the molecular mechanisms that underlie TRP channel disturbance. This brief review summarizes current knowledge of the molecular role of TRP channels in the development and progression of pancreatic ductal carcinoma to identify potential therapeutic interventions.https://www.mdpi.com/2673-9992/21/1/9pancreatic cancerductal carcinomaadenocarcinomatumorTRP channelpathogenesis |
| spellingShingle | Ahmad Taha Khalaf Yuanyuan Wei Samiah Yasmin Abdul Kadir Jamaludin Zainol Zahraa Oglah TRP Channels Interactome in Pancreatic Ductal Adenocarcinoma: A Potential Therapeutic Target Medical Sciences Forum pancreatic cancer ductal carcinoma adenocarcinoma tumor TRP channel pathogenesis |
| title | TRP Channels Interactome in Pancreatic Ductal Adenocarcinoma: A Potential Therapeutic Target |
| title_full | TRP Channels Interactome in Pancreatic Ductal Adenocarcinoma: A Potential Therapeutic Target |
| title_fullStr | TRP Channels Interactome in Pancreatic Ductal Adenocarcinoma: A Potential Therapeutic Target |
| title_full_unstemmed | TRP Channels Interactome in Pancreatic Ductal Adenocarcinoma: A Potential Therapeutic Target |
| title_short | TRP Channels Interactome in Pancreatic Ductal Adenocarcinoma: A Potential Therapeutic Target |
| title_sort | trp channels interactome in pancreatic ductal adenocarcinoma a potential therapeutic target |
| topic | pancreatic cancer ductal carcinoma adenocarcinoma tumor TRP channel pathogenesis |
| url | https://www.mdpi.com/2673-9992/21/1/9 |
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