Aiming for More Sustainable Cross-Coupling Chemistry by Employing Single-Atom Catalysis on Scale
Scaling up syntheses from mg to kg quantities is a complex endeavor. Besides adapting laboratory protocols to industrial processes and equipment and thorough safety assessments, much attention is paid to the reduction of the process’ environmental impact. For processes including transition metal ca...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2023-03-01
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| Series: | CHIMIA |
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| Online Access: | https://chimia.ch/chimia/article/view/6252 |
| _version_ | 1797838006807166976 |
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| author | Dario Poier Sharon Mitchell Victor Tulus Gonzalo Guillén-Gosálbez Javier Pérez-Ramírez Roger Marti |
| author_facet | Dario Poier Sharon Mitchell Victor Tulus Gonzalo Guillén-Gosálbez Javier Pérez-Ramírez Roger Marti |
| author_sort | Dario Poier |
| collection | DOAJ |
| description |
Scaling up syntheses from mg to kg quantities is a complex endeavor. Besides adapting laboratory protocols to industrial processes and equipment and thorough safety assessments, much attention is paid to the reduction of the process’ environmental impact. For processes including transition metal catalyzed steps, e.g. cross-coupling chemistry, this impact strongly depends on the identity of the metal used. As such, a key approach is the replacement of single-use with reusable heterogeneous catalysts. Transition metal single-atom heterogeneous catalysts (SAC), a novel class of catalytic materials, might exhibit all the necessary properties to step up to this task. This article shall discuss current applications of SAC in cross-coupling chemistry from the point of a process chemist and shed light on the NCCR Catalysis contribution to the field. Investigations of the stability-activity-selectivity relationship of SACs in combination with early-stage life-cycle assessments (LCA) of potential processes lay the foundation for large-scale application tailored catalyst synthesis. Ultimately, prevailing challenges are highlighted, which need to be addressed in future research.
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| first_indexed | 2024-04-09T15:34:55Z |
| format | Article |
| id | doaj.art-ddba2aaa50394575854b816cae1df4b2 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-04-09T15:34:55Z |
| publishDate | 2023-03-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-ddba2aaa50394575854b816cae1df4b22023-04-28T00:08:19ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242023-03-0177310.2533/chimia.2023.127Aiming for More Sustainable Cross-Coupling Chemistry by Employing Single-Atom Catalysis on ScaleDario Poier0Sharon Mitchell1Victor Tulus2Gonzalo Guillén-Gosálbez3Javier Pérez-Ramírez4Roger Marti5Institute of Chemical Technology, Haute école d’Ingénierie et d’Architecture Fribourg, HES-SO University of Applied Sciences and Arts Western Switzerland, Boulevard de Pérolles 80, CH-1700 Fribourg; Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir- Prelog-Weg 1, CH-8093 ZurichInstitute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir- Prelog-Weg 1, CH-8093 ZurichInstitute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir- Prelog-Weg 1, CH-8093 ZurichInstitute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir- Prelog-Weg 1, CH-8093 ZurichInstitute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir- Prelog-Weg 1, CH-8093 ZurichInstitute of Chemical Technology, Haute école d’Ingénierie et d’Architecture Fribourg, HES-SO University of Applied Sciences and Arts Western Switzerland, Boulevard de Pérolles 80, CH-1700 Fribourg Scaling up syntheses from mg to kg quantities is a complex endeavor. Besides adapting laboratory protocols to industrial processes and equipment and thorough safety assessments, much attention is paid to the reduction of the process’ environmental impact. For processes including transition metal catalyzed steps, e.g. cross-coupling chemistry, this impact strongly depends on the identity of the metal used. As such, a key approach is the replacement of single-use with reusable heterogeneous catalysts. Transition metal single-atom heterogeneous catalysts (SAC), a novel class of catalytic materials, might exhibit all the necessary properties to step up to this task. This article shall discuss current applications of SAC in cross-coupling chemistry from the point of a process chemist and shed light on the NCCR Catalysis contribution to the field. Investigations of the stability-activity-selectivity relationship of SACs in combination with early-stage life-cycle assessments (LCA) of potential processes lay the foundation for large-scale application tailored catalyst synthesis. Ultimately, prevailing challenges are highlighted, which need to be addressed in future research. https://chimia.ch/chimia/article/view/6252Cross-Coupling ReactionsLife-cycle assessmentProcess ChemistrySingle-Atom CatalysisSustainability |
| spellingShingle | Dario Poier Sharon Mitchell Victor Tulus Gonzalo Guillén-Gosálbez Javier Pérez-Ramírez Roger Marti Aiming for More Sustainable Cross-Coupling Chemistry by Employing Single-Atom Catalysis on Scale CHIMIA Cross-Coupling Reactions Life-cycle assessment Process Chemistry Single-Atom Catalysis Sustainability |
| title | Aiming for More Sustainable Cross-Coupling Chemistry by Employing Single-Atom Catalysis on Scale |
| title_full | Aiming for More Sustainable Cross-Coupling Chemistry by Employing Single-Atom Catalysis on Scale |
| title_fullStr | Aiming for More Sustainable Cross-Coupling Chemistry by Employing Single-Atom Catalysis on Scale |
| title_full_unstemmed | Aiming for More Sustainable Cross-Coupling Chemistry by Employing Single-Atom Catalysis on Scale |
| title_short | Aiming for More Sustainable Cross-Coupling Chemistry by Employing Single-Atom Catalysis on Scale |
| title_sort | aiming for more sustainable cross coupling chemistry by employing single atom catalysis on scale |
| topic | Cross-Coupling Reactions Life-cycle assessment Process Chemistry Single-Atom Catalysis Sustainability |
| url | https://chimia.ch/chimia/article/view/6252 |
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