What is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trails
Abstract Background There is conflicting evidence on the effect of vitamin D on glycemic control. Therefore, in the current meta-analyses, we aimed to assess the effect of vitamin D supplementation on the glycemic control of type 2 diabetes (T2D) patients. Methods We conducted a comprehensive search...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-022-01209-x |
| _version_ | 1797945909629157376 |
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| author | Mohammad Ashraf Farahmand Elnaz Daneshzad Teresa T. Fung Fawzia Zahidi Maryam Muhammadi Nick Bellissimo Leila Azadbakht |
| author_facet | Mohammad Ashraf Farahmand Elnaz Daneshzad Teresa T. Fung Fawzia Zahidi Maryam Muhammadi Nick Bellissimo Leila Azadbakht |
| author_sort | Mohammad Ashraf Farahmand |
| collection | DOAJ |
| description | Abstract Background There is conflicting evidence on the effect of vitamin D on glycemic control. Therefore, in the current meta-analyses, we aimed to assess the effect of vitamin D supplementation on the glycemic control of type 2 diabetes (T2D) patients. Methods We conducted a comprehensive search in electronic databases including; PubMed/Medline, Web of Science, Scopus, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and NIH’s Clinical Trials Registry, from the inception of each database up to January first, 2021. Results A total of 46 randomized controlled trials (RCTs) consisting of 2164 intervention subjects and 2149 placebo controls were included in this meta-analysis. Pooled analyses for HbA1c showed a significant change between the intervention and placebo group, the weighted mean difference (WMD)(95% confidence interval(CI)) was -0.20%(-0.29, -0.11) with P < 0.001. Analyses for assessing changes in FPG found a significant reduction in the intervention group after vitamin D supplementation, the WMD (95%CI) was -5.02 mg/dl (-6.75,-3.28) with P < 0.001. The result of pooled analyses for HOMA-IR revealed a significant change between the intervention and control group, the WMD (95%CI) was -0.42(-0.76, -0.07) with P = 0.019. The subgroup analyses showed the most efficacy in a higher dose and short intervention period and in subjects with deficient vitamin D status. Conclusion Vitamin D supplementation might be beneficial for the reduction of FPG, HbA1c, and HOMA-IR in type 2 diabetes patients with deficient vitamin D status. This effect was especially prominent when vitamin D was given in large doses and for a short period of time albeit with substantial heterogeneity between studies and a probability of publication bias. |
| first_indexed | 2024-04-10T21:02:35Z |
| format | Article |
| id | doaj.art-ddbb9a09850942a2b516e5f66d1dd9f9 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-10T21:02:35Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-ddbb9a09850942a2b516e5f66d1dd9f92023-01-22T12:16:19ZengBMCBMC Endocrine Disorders1472-68232023-01-0123111410.1186/s12902-022-01209-xWhat is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trailsMohammad Ashraf Farahmand0Elnaz Daneshzad1Teresa T. Fung2Fawzia Zahidi3Maryam Muhammadi4Nick Bellissimo5Leila Azadbakht6Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS)Non-Communicable Diseases Research Center, Alborz University of Medical SciencesDepartment of Nutrition, Harvard TH Chan School of Public HealthDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS)Critical Nursing Care Department, Kabul University of Medical Science (KUMS)School of Nutrition, Toronto Metropolitan UniversityDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS)Abstract Background There is conflicting evidence on the effect of vitamin D on glycemic control. Therefore, in the current meta-analyses, we aimed to assess the effect of vitamin D supplementation on the glycemic control of type 2 diabetes (T2D) patients. Methods We conducted a comprehensive search in electronic databases including; PubMed/Medline, Web of Science, Scopus, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and NIH’s Clinical Trials Registry, from the inception of each database up to January first, 2021. Results A total of 46 randomized controlled trials (RCTs) consisting of 2164 intervention subjects and 2149 placebo controls were included in this meta-analysis. Pooled analyses for HbA1c showed a significant change between the intervention and placebo group, the weighted mean difference (WMD)(95% confidence interval(CI)) was -0.20%(-0.29, -0.11) with P < 0.001. Analyses for assessing changes in FPG found a significant reduction in the intervention group after vitamin D supplementation, the WMD (95%CI) was -5.02 mg/dl (-6.75,-3.28) with P < 0.001. The result of pooled analyses for HOMA-IR revealed a significant change between the intervention and control group, the WMD (95%CI) was -0.42(-0.76, -0.07) with P = 0.019. The subgroup analyses showed the most efficacy in a higher dose and short intervention period and in subjects with deficient vitamin D status. Conclusion Vitamin D supplementation might be beneficial for the reduction of FPG, HbA1c, and HOMA-IR in type 2 diabetes patients with deficient vitamin D status. This effect was especially prominent when vitamin D was given in large doses and for a short period of time albeit with substantial heterogeneity between studies and a probability of publication bias.https://doi.org/10.1186/s12902-022-01209-xVitamin DSupplementationType 2 diabetesGlycemic controlSystematic reviewMeta-analyses |
| spellingShingle | Mohammad Ashraf Farahmand Elnaz Daneshzad Teresa T. Fung Fawzia Zahidi Maryam Muhammadi Nick Bellissimo Leila Azadbakht What is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trails BMC Endocrine Disorders Vitamin D Supplementation Type 2 diabetes Glycemic control Systematic review Meta-analyses |
| title | What is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trails |
| title_full | What is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trails |
| title_fullStr | What is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trails |
| title_full_unstemmed | What is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trails |
| title_short | What is the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review and meta-analysis of randomized controlled trails |
| title_sort | what is the impact of vitamin d supplementation on glycemic control in people with type 2 diabetes a systematic review and meta analysis of randomized controlled trails |
| topic | Vitamin D Supplementation Type 2 diabetes Glycemic control Systematic review Meta-analyses |
| url | https://doi.org/10.1186/s12902-022-01209-x |
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