Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells
Abstract Objective Osteopontin (OPN) is a well-known glycoprotein involved in numerous pathobiological processes, including cancer. Despite having five splice variants for osteopontin in mice, the main focus of most studies has been on total OPN (tOPN). There are some studies on other splice variant...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-022-06179-w |
| _version_ | 1828735403638652928 |
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| author | Mohammad Kamalabadi-Farahani Amir Atashi Zahra Jabbarpour Seyed Sajjad Aghayan |
| author_facet | Mohammad Kamalabadi-Farahani Amir Atashi Zahra Jabbarpour Seyed Sajjad Aghayan |
| author_sort | Mohammad Kamalabadi-Farahani |
| collection | DOAJ |
| description | Abstract Objective Osteopontin (OPN) is a well-known glycoprotein involved in numerous pathobiological processes, including cancer. Despite having five splice variants for osteopontin in mice, the main focus of most studies has been on total OPN (tOPN). There are some studies on other splice variants, but the expression of osteopontin-5 (OPN5) has not been addressed in mouse cancer cells. Therefore, this study sought to evaluate OPN5 expression in mouse breast cancer cells. Results The expression of OPN5 in primary and metastatic breast cancer cells of mice was confirmed in our study. These findings provided important insights regarding the OPN alternative splicing in mice for the first time. It is concluded that, like other OPN-SVs, OPN5 probably plays an essential role in tumor progression, which requires further investigation in different tumor models. |
| first_indexed | 2024-04-12T23:06:16Z |
| format | Article |
| id | doaj.art-ddbc58588eb849e3babc426e55a37d09 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-04-12T23:06:16Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-ddbc58588eb849e3babc426e55a37d092022-12-22T03:12:55ZengBMCBMC Research Notes1756-05002022-09-011511510.1186/s13104-022-06179-wExpression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cellsMohammad Kamalabadi-Farahani0Amir Atashi1Zahra Jabbarpour2Seyed Sajjad Aghayan3Department of Tissue Engineering, School of Medicine, Shahroud University of Medical SciencesDepartment of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahroud University of Medical SciencesGene Therapy Research Center, Digestive Disease Research Institute, Tehran University of Medical SciencesGene Therapy Research Center, Digestive Disease Research Institute, Tehran University of Medical SciencesAbstract Objective Osteopontin (OPN) is a well-known glycoprotein involved in numerous pathobiological processes, including cancer. Despite having five splice variants for osteopontin in mice, the main focus of most studies has been on total OPN (tOPN). There are some studies on other splice variants, but the expression of osteopontin-5 (OPN5) has not been addressed in mouse cancer cells. Therefore, this study sought to evaluate OPN5 expression in mouse breast cancer cells. Results The expression of OPN5 in primary and metastatic breast cancer cells of mice was confirmed in our study. These findings provided important insights regarding the OPN alternative splicing in mice for the first time. It is concluded that, like other OPN-SVs, OPN5 probably plays an essential role in tumor progression, which requires further investigation in different tumor models.https://doi.org/10.1186/s13104-022-06179-wOsteopontin-5Breast cancerSplice variantsAlternative splicingMetastasis |
| spellingShingle | Mohammad Kamalabadi-Farahani Amir Atashi Zahra Jabbarpour Seyed Sajjad Aghayan Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells BMC Research Notes Osteopontin-5 Breast cancer Splice variants Alternative splicing Metastasis |
| title | Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells |
| title_full | Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells |
| title_fullStr | Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells |
| title_full_unstemmed | Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells |
| title_short | Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells |
| title_sort | expression of osteopontin 5 splice variant in the mouse primary and metastatic breast cancer cells |
| topic | Osteopontin-5 Breast cancer Splice variants Alternative splicing Metastasis |
| url | https://doi.org/10.1186/s13104-022-06179-w |
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