Advances in Serological Diagnosis of Neurocysticercosis in Korea
Cysticercosis, a parasitic disease caused by Taenia solium metacestode (TsM), has a major global public health impact in terms of disability-adjusted life years. The parasite preferentially infects subcutaneous tissue, but may invade the central nervous system, resulting in neurocysticercosis (NC)....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Korea Genome Organization
2019-03-01
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| Series: | Genomics & Informatics |
| Subjects: | |
| Online Access: | http://genominfo.org/upload/pdf/gi-2019-17-1-e7.pdf |
| _version_ | 1819023903922585600 |
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| author | Chun-Seob Ahn Jeong-Geun Kim Sun Huh Insug Kang Yoon Kong |
| author_facet | Chun-Seob Ahn Jeong-Geun Kim Sun Huh Insug Kang Yoon Kong |
| author_sort | Chun-Seob Ahn |
| collection | DOAJ |
| description | Cysticercosis, a parasitic disease caused by Taenia solium metacestode (TsM), has a major global public health impact in terms of disability-adjusted life years. The parasite preferentially infects subcutaneous tissue, but may invade the central nervous system, resulting in neurocysticercosis (NC). NC is an important neglected tropical disease and an emerging disease in industrialized countries due to immigration from endemic areas. The prevalence of taeniasis in Korea declined from 0.3%–12.7% during the 1970s to below 0.02% since the 2000s. A survey conducted from 1993 to 2006 revealed that the percentage of tested samples with high levels of specific anti-TsM antibody declined from 8.3% to 2.2%, suggesting the continuing occurrence of NC in Korea. Modern imaging modalities have substantially improved the diagnostic accuracy of NC, and recent advances in the molecular biochemical characterization of the TsM cyst fluid proteome also significantly strengthened NC serodiagnosis. Two glycoproteins of 150 and 120 kDa that induce strong antibody responses against sera from patients with active-stage NC have been elucidated. The 150 kDa protein showed hydrophobic-ligand binding activities and might be critically involved in the acquisition of host-derived lipid molecules. Fasciclin and endophilin B1, both of which play roles in the homeostatic functions of TsM, showed fairly high antibody responses against calcified NC cases. NC is now controllable and manageable. Further studies should focus on controlling late-onset intractable seizures and serological diagnosis of NC patients infected with few worms. This article briefly overviews diagnostic approaches and discusses current issues relating to NC serodiagnosis. |
| first_indexed | 2024-12-21T04:46:18Z |
| format | Article |
| id | doaj.art-ddbc9529347d4eb898a6a909256b76b2 |
| institution | Directory Open Access Journal |
| issn | 2234-0742 |
| language | English |
| last_indexed | 2024-12-21T04:46:18Z |
| publishDate | 2019-03-01 |
| publisher | Korea Genome Organization |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj.art-ddbc9529347d4eb898a6a909256b76b22022-12-21T19:15:33ZengKorea Genome OrganizationGenomics & Informatics2234-07422019-03-0117110.5808/GI.2019.17.1.e7550Advances in Serological Diagnosis of Neurocysticercosis in KoreaChun-Seob Ahn0Jeong-Geun Kim1Sun Huh2Insug Kang3Yoon Kong4 Department of Molecular Parasitology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon 16419, Korea Department of Molecular Parasitology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon 16419, Korea Department of Parasitology and Institute of Medical Education, Hallym University College of Medicine, Chuncheon 24252, Korea Department of Biochemistry and Molecular Biology, Kyung Hee University College of Medicine, Seoul 02447, Korea Department of Molecular Parasitology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon 16419, KoreaCysticercosis, a parasitic disease caused by Taenia solium metacestode (TsM), has a major global public health impact in terms of disability-adjusted life years. The parasite preferentially infects subcutaneous tissue, but may invade the central nervous system, resulting in neurocysticercosis (NC). NC is an important neglected tropical disease and an emerging disease in industrialized countries due to immigration from endemic areas. The prevalence of taeniasis in Korea declined from 0.3%–12.7% during the 1970s to below 0.02% since the 2000s. A survey conducted from 1993 to 2006 revealed that the percentage of tested samples with high levels of specific anti-TsM antibody declined from 8.3% to 2.2%, suggesting the continuing occurrence of NC in Korea. Modern imaging modalities have substantially improved the diagnostic accuracy of NC, and recent advances in the molecular biochemical characterization of the TsM cyst fluid proteome also significantly strengthened NC serodiagnosis. Two glycoproteins of 150 and 120 kDa that induce strong antibody responses against sera from patients with active-stage NC have been elucidated. The 150 kDa protein showed hydrophobic-ligand binding activities and might be critically involved in the acquisition of host-derived lipid molecules. Fasciclin and endophilin B1, both of which play roles in the homeostatic functions of TsM, showed fairly high antibody responses against calcified NC cases. NC is now controllable and manageable. Further studies should focus on controlling late-onset intractable seizures and serological diagnosis of NC patients infected with few worms. This article briefly overviews diagnostic approaches and discusses current issues relating to NC serodiagnosis.http://genominfo.org/upload/pdf/gi-2019-17-1-e7.pdfimmunodiagnosisneurocysticercosisproteomeRepublic of Korea |
| spellingShingle | Chun-Seob Ahn Jeong-Geun Kim Sun Huh Insug Kang Yoon Kong Advances in Serological Diagnosis of Neurocysticercosis in Korea Genomics & Informatics immunodiagnosis neurocysticercosis proteome Republic of Korea |
| title | Advances in Serological Diagnosis of Neurocysticercosis in Korea |
| title_full | Advances in Serological Diagnosis of Neurocysticercosis in Korea |
| title_fullStr | Advances in Serological Diagnosis of Neurocysticercosis in Korea |
| title_full_unstemmed | Advances in Serological Diagnosis of Neurocysticercosis in Korea |
| title_short | Advances in Serological Diagnosis of Neurocysticercosis in Korea |
| title_sort | advances in serological diagnosis of neurocysticercosis in korea |
| topic | immunodiagnosis neurocysticercosis proteome Republic of Korea |
| url | http://genominfo.org/upload/pdf/gi-2019-17-1-e7.pdf |
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