Comparative effectiveness of spirapril and enalapril in patients with coronary heart disease-caused chronic heart failure
Aim. During prospective 6-month follow-up, to compare spirapril and enalapril effectiveness in patients with coronary heart disease (CHD)-caused chronic heart failure (CHF). Material and methods. In total, 61 patients with CHD-caused CHF, according to inclusion/exclusion criteria, were divided into...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2006-08-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1242 |
| _version_ | 1797882770125488128 |
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| author | S, Yu. Volkova V. V. Ragozina V. A. Balina M. A. Pushnikova V. A. Shchupletsova S. V. Shalaev |
| author_facet | S, Yu. Volkova V. V. Ragozina V. A. Balina M. A. Pushnikova V. A. Shchupletsova S. V. Shalaev |
| author_sort | S, Yu. Volkova |
| collection | DOAJ |
| description | Aim. During prospective 6-month follow-up, to compare spirapril and enalapril effectiveness in patients with coronary heart disease (CHD)-caused chronic heart failure (CHF). Material and methods. In total, 61 patients with CHD-caused CHF, according to inclusion/exclusion criteria, were divided into spirapril group (n=29; mean dose 5±1.3 mg/d) and enalapril group (n=32, mean dose 18.3±9.0 mg/ d). At baseline and after 6-month follow-up, all patients underwent general clinical examination, 6-minute walking test, echocardiography (EchoCG), and quantitative measurement of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) level. Data analysis was performed with STATISTICA package (Version 6.0). Results. Both agents had similar clinical effects: during follow-up, left ventricular ejection fraction (LVEF) increased by 9.6% in spirapril group (р=0.00013), and by 7.0% in enalapril group (р=0.01). In 6-minute walking test, the distance walked increased by 25.1% (р=0.00016) and 14.8% (р=0.01), respectively. NT-proBNP levels significantly correlated with patients’ functional status, assessed in 6-minute walking test (r=-0.43, p=0.002), and EchoCG-assessed LF systolic dysfunction (r=-0.46, p=0.001). In both groups, NT-proBNP levels had raised: non-significantly, up to 25 pmol/l (р=0.66) in spirapril group, and significantly, up to 150 pmol/l (р=0.045), in enalapril group. Conclusion. In patients with CHD-caused CHF, spirapril was as clinically effective as a traditionally administered ACE inhibitor. Spirapril was more effective in delaying NT-proBNP level increase. |
| first_indexed | 2024-04-10T03:41:02Z |
| format | Article |
| id | doaj.art-ddbf62e39f34478fb3c858dcf0c14347 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:41:02Z |
| publishDate | 2006-08-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-ddbf62e39f34478fb3c858dcf0c143472023-03-13T07:23:12Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252006-08-01547581953Comparative effectiveness of spirapril and enalapril in patients with coronary heart disease-caused chronic heart failureS, Yu. Volkova0V. V. Ragozina1V. A. Balina2M. A. Pushnikova3V. A. Shchupletsova4S. V. Shalaev5Институт терапии Тюменского Отдела Южно-Уральского научного центра РАМН; Тюменская государственная медицинская академия. ТюменьОбластной кардиологический диспансерОбластной кардиологический диспансерТюменская государственная медицинская академия. ТюменьТюменская государственная медицинская академия. ТюменьОбластной кардиологический диспансер; Тюменская государственная медицинская академия. ТюменьAim. During prospective 6-month follow-up, to compare spirapril and enalapril effectiveness in patients with coronary heart disease (CHD)-caused chronic heart failure (CHF). Material and methods. In total, 61 patients with CHD-caused CHF, according to inclusion/exclusion criteria, were divided into spirapril group (n=29; mean dose 5±1.3 mg/d) and enalapril group (n=32, mean dose 18.3±9.0 mg/ d). At baseline and after 6-month follow-up, all patients underwent general clinical examination, 6-minute walking test, echocardiography (EchoCG), and quantitative measurement of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) level. Data analysis was performed with STATISTICA package (Version 6.0). Results. Both agents had similar clinical effects: during follow-up, left ventricular ejection fraction (LVEF) increased by 9.6% in spirapril group (р=0.00013), and by 7.0% in enalapril group (р=0.01). In 6-minute walking test, the distance walked increased by 25.1% (р=0.00016) and 14.8% (р=0.01), respectively. NT-proBNP levels significantly correlated with patients’ functional status, assessed in 6-minute walking test (r=-0.43, p=0.002), and EchoCG-assessed LF systolic dysfunction (r=-0.46, p=0.001). In both groups, NT-proBNP levels had raised: non-significantly, up to 25 pmol/l (р=0.66) in spirapril group, and significantly, up to 150 pmol/l (р=0.045), in enalapril group. Conclusion. In patients with CHD-caused CHF, spirapril was as clinically effective as a traditionally administered ACE inhibitor. Spirapril was more effective in delaying NT-proBNP level increase.https://cardiovascular.elpub.ru/jour/article/view/1242хроническая сердечная недостаточностьсравнение иапфспираприлэнлаприлnt-probnp |
| spellingShingle | S, Yu. Volkova V. V. Ragozina V. A. Balina M. A. Pushnikova V. A. Shchupletsova S. V. Shalaev Comparative effectiveness of spirapril and enalapril in patients with coronary heart disease-caused chronic heart failure Кардиоваскулярная терапия и профилактика хроническая сердечная недостаточность сравнение иапф спираприл энлаприл nt-probnp |
| title | Comparative effectiveness of spirapril and enalapril in patients with coronary heart disease-caused chronic heart failure |
| title_full | Comparative effectiveness of spirapril and enalapril in patients with coronary heart disease-caused chronic heart failure |
| title_fullStr | Comparative effectiveness of spirapril and enalapril in patients with coronary heart disease-caused chronic heart failure |
| title_full_unstemmed | Comparative effectiveness of spirapril and enalapril in patients with coronary heart disease-caused chronic heart failure |
| title_short | Comparative effectiveness of spirapril and enalapril in patients with coronary heart disease-caused chronic heart failure |
| title_sort | comparative effectiveness of spirapril and enalapril in patients with coronary heart disease caused chronic heart failure |
| topic | хроническая сердечная недостаточность сравнение иапф спираприл энлаприл nt-probnp |
| url | https://cardiovascular.elpub.ru/jour/article/view/1242 |
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