Methotrexate Disposition, Anti-Folate Activity, and Metabolomic Profiling to Identify Molecular Markers of Disease Activity and Drug Response in the Collagen-Induced Arthritis Mouse Model

Methotrexate Disposition, Anti-Folate Activity, and Metabolomic Profiling to Identify Molecular Markers of Disease Activity and Drug Response in the Collagen-Induced Arthritis Mouse Model

Methotrexate (MTX) is widely used in the treatment of autoimmune arthritis but is limited by its unpredictable and variable response profile. Currently, no biomarkers exist to predict or monitor early therapeutic responses to MTX. Using a collagen-induced arthritis (CIA) mouse model, this study aime...

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Bibliographic Details
Main Authors: Yezan M. Salamoun, Kishore Polireddy, Yu Kyoung Cho, Matthew R. Medcalf, Ryan S. Funk
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Metabolites
Subjects:
metabolomics
rheumatoid arthritis
methotrexate
biomarkers
plasma metabolome
collagen-induced arthritis
Online Access:https://www.mdpi.com/2218-1989/12/1/24

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