2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis

2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis

Abstract Background Osteosarcoma is a malignant bone tumor that usually affects adolescents aged 15–19 y. The DNA damage response (DDR) is significantly enhanced in osteosarcoma, impairing the effect of systemic chemotherapy. Targeting the DDR process was considered a feasible strategy benefitting o...

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Bibliographic Details
Main Authors: Doudou Jing, Xuanzuo Chen, Zhenhao Zhang, Fengxia Chen, Fuhua Huang, Zhicai Zhang, Wei Wu, Zengwu Shao, Feifei Pu
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Molecular Medicine
Subjects:
2-Hydroxy-3-methylanthraquinone
DNA damage response (DDR)
MYC
CHK1
RAD51
Online Access:https://doi.org/10.1186/s10020-023-00611-y

Internet

https://doi.org/10.1186/s10020-023-00611-y

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