Phenotypic analysis of images of zebrafish treated with Alzheimer's γ-secretase inhibitors

Phenotypic analysis of images of zebrafish treated with Alzheimer's γ-secretase inhibitors

<p>Abstract</p> <p>Background</p> <p>Several γ-secretase inhibitors (GSI) are in clinical trials for the treatment of Alzheimer's disease (AD). This enzyme mediates the proteolytic cleavage of amyloid precursor protein (APP) to generate amyloid β protein, Aβ, the p...

Full description

Bibliographic Details
Main Authors:	Augelli-Szafran Corinne E, Wong Stephen T, Xu Xiaoyin, Yang Ting, Arslanova Dilyara, Xia Weiming
Format:	Article
Language:	English
Published:	BMC 2010-03-01
Series:	BMC Biotechnology
Online Access:	http://www.biomedcentral.com/1472-6750/10/24

Similar Items

Turning the tide on Alzheimer’s disease: modulation of γ-secretase
by: Joanna E. Luo, et al.
Published: (2022-01-01)

FAD Mutations in Presenilin-1 or Amyloid Precursor Protein Decrease the Efficacy of a γ-Secretase Inhibitor: Evidence for Direct Involvement of PS1 in the γ-Secretase Cleavage Complex
by: Weiming Xia, et al.
Published: (2000-12-01)

γ-secretase inhibitors and modulators induce distinct conformational changes in the active sites of γ-secretase and signal peptide peptidase
by: Gertsik, Natalya, et al.
Published: (2015)

Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease
by: Michael S. Wolfe
Published: (2021-01-01)

BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer’s Disease
by: Miguel A. Maia, et al.
Published: (2019-03-01)

The evolved divergence of γ-secretase-susceptibility of homologous proteins Ngfrb and Nradd in zebrafish
by: Tanya Jayne, et al.
Published: (2021-12-01)

Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration
by: Hermien Acx, et al.
Published: (2017-08-01)

Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes
by: Sujan Devkota, et al.
Published: (2024-02-01)

Functional γ-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and γ-secretase substrates
by: Stephanie Baulac, et al.
Published: (2003-11-01)

A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.
by: April M Weissmiller, et al.
Published: (2015-01-01)

γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct
by: Yong Ran, et al.
Published: (2017-07-01)

Evaluation of Virtual Screening Strategies for the Identification of γ-Secretase Inhibitors and Modulators
by: Alicia Ioppolo, et al.
Published: (2021-12-01)

Effects of the γ-secretase inhibitor semagacestat on hippocampal neuronal network oscillation
by: Mihaly eHajos, et al.
Published: (2013-06-01)

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
by: Christian B. Lessard, et al.
Published: (2020-05-01)

Presenilins and γ-Secretase in Membrane Proteostasis
by: Naoto Oikawa, et al.
Published: (2019-03-01)

Structure-function relationship of γ-secretase
by: Tomita Taisuke
Published: (2012-02-01)

Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes
by: Jun Wang, et al.
Published: (2004-04-01)

Generation of an apoptotic intracellular peptide by γ-secretase cleavage of Alzheimer's amyloid β protein precursor
by: Passer, B, et al.
Published: (2000)

Structural Analysis of the Simultaneous Activation and Inhibition of γ-Secretase Activity in the Development of Drugs for Alzheimer’s Disease
by: Željko M. Svedružić, et al.
Published: (2021-04-01)

Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease.
by: Zeljko M Svedružić, et al.
Published: (2012-01-01)

Modulators of γ-secretase activity can facilitate the toxic side-effects and pathogenesis of Alzheimer's disease.
by: Željko M Svedružić, et al.
Published: (2013-01-01)

Mechanisms of γ‑Secretase Activation and Substrate Processing
by: Apurba Bhattarai, et al.
Published: (2020-06-01)

Inhibition of Notch signaling by a γ-secretase inhibitor attenuates hepatic fibrosis in rats.
by: Yixiong Chen, et al.
Published: (2012-01-01)

Hair Cell Generation in Cochlear Culture Models Mediated by Novel γ-Secretase Inhibitors
by: Silvia T. Erni, et al.
Published: (2021-08-01)

γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors
by: Eitan Wong, et al.
Published: (2020-12-01)

Correction: Modulators of γ-Secretase Activity Can Facilitate the Toxic Side-Effects and Pathogenesis of Alzheimer's Disease
Published: (2013-01-01)

Correction: Modulators of γ-Secretase Activity Can Facilitate the Toxic Side-Effects and Pathogenesis of Alzheimer's Disease.
by: Željko M. Svedružić, et al.
Published: (2013-01-01)

ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
by: Bing Zhu, et al.
Published: (2017-11-01)

How γ-secretase hits a moving target
by: Charles R Sanders
Published: (2016-08-01)

Visualization of PS/γ-Secretase Activity in Living Cells
by: Masato Maesako, et al.
Published: (2020-06-01)

Presenilins and the γ-secretase: still a complex problem
by: Small David H, et al.
Published: (2010-02-01)

Γ-secretase components as predictors of breast cancer outcome.
by: Hanna M Peltonen, et al.
Published: (2013-01-01)

Role of cholesterol in substrate recognition by $$\gamma$$ γ -secretase
by: Łukasz Nierzwicki, et al.
Published: (2021-07-01)

Unlocking the Secrets of Cancer Stem Cells with γ-Secretase Inhibitors: A Novel Anticancer Strategy
by: Maryam Ghanbari-Movahed, et al.
Published: (2021-02-01)

Changes in alpha- and beta-secretase in Alzheimer's disease
by: Tyler, S, et al.
Published: (2003)

Amylin and Secretases in the Pathology and Treatment of Alzheimer’s Disease
by: Som Singh, et al.
Published: (2022-07-01)

Concatenation of molecular docking and molecular simulation of BACE-1, γ-secretase targeted ligands: in pursuit of Alzheimer’s treatment
by: Nasimudeen R. Jabir, et al.
Published: (2021-01-01)

Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein
by: Hung N. Do, et al.
Published: (2023-02-01)

γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43
by: Masayasu Okochi, et al.
Published: (2013-01-01)

RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing
by: Xie Zhongcong, et al.
Published: (2012-03-01)