The Methionine 549 and Leucine 552 Residues of Friedelin Synthase from <i>Maytenus ilicifolia</i> Are Important for Substrate Binding Specificity

The Methionine 549 and Leucine 552 Residues of Friedelin Synthase from <i>Maytenus ilicifolia</i> Are Important for Substrate Binding Specificity

Friedelin, a pentacyclic triterpene found in the leaves of the Celastraceae species, demonstrates numerous biological activities and is a precursor of quinonemethide triterpenes, which are promising antitumoral agents. Friedelin is biosynthesized from the cyclization of 2,3-oxidosqualene, involving...

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Bibliographic Details
Main Authors: Bruna F. Mazzeu, Tatiana M. Souza-Moreira, Andrew A. Oliveira, Melissa Remlinger, Lidiane G. Felippe, Sandro R. Valentini, Rafael V. C. Guido, Cleslei F. Zanelli, Maysa Furlan
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
<i>Maytenus ilicifolia</i>
Celastraceae
<i>Saccharomyces cerevisiae</i>
friedelin synthase
site-directed mutation
Met549Ser
Online Access:https://www.mdpi.com/1420-3049/26/22/6806

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