3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia
The non-coding genome of T-ALL has not been extensively studied. Here, the authors conduct RNA-seq, ATAC-seq and Hi-C seq analyses and find that T-ALL associated neo-loops may regulate key transcription factors including HOXA13; the aberrant expression of which is associated with poor prognosis.
Bibliographic Details
| Main Authors: |
Lu Yang,
Fengling Chen,
Haichuan Zhu,
Yang Chen,
Bingjie Dong,
Minglei Shi,
Weitao Wang,
Qian Jiang,
Leping Zhang,
Xiaojun Huang,
Michael Q. Zhang,
Hong Wu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-24044-5
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