The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)
Non-O blood groups are associated with decreased insulin sensitivity and risk of type 2 diabetes. A recent study pinpointed the associations between ABO blood groups and gut microbiome, which may serve as potential mediators for the observed increased disease risks. We aimed to characterize associat...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/12/9/787 |
| _version_ | 1827658979702996992 |
|---|---|
| author | Ruifang Li-Gao Kirk Grubbs Alain G. Bertoni Kristi L. Hoffman Joseph F. Petrosino Gautam Ramesh Martin Wu Jerome I. Rotter Yii-Der Ida Chen Anne M. Evans Richard J. Robinson Laura Sommerville Dennis Mook-Kanamori Mark O. Goodarzi Gregory A. Michelotti Patricia A. Sheridan |
| author_facet | Ruifang Li-Gao Kirk Grubbs Alain G. Bertoni Kristi L. Hoffman Joseph F. Petrosino Gautam Ramesh Martin Wu Jerome I. Rotter Yii-Der Ida Chen Anne M. Evans Richard J. Robinson Laura Sommerville Dennis Mook-Kanamori Mark O. Goodarzi Gregory A. Michelotti Patricia A. Sheridan |
| author_sort | Ruifang Li-Gao |
| collection | DOAJ |
| description | Non-O blood groups are associated with decreased insulin sensitivity and risk of type 2 diabetes. A recent study pinpointed the associations between ABO blood groups and gut microbiome, which may serve as potential mediators for the observed increased disease risks. We aimed to characterize associations between ABO haplotypes and insulin-related traits as well as potential mediating pathways. We assessed insulin homeostasis in African Americans (AAs; <i>n</i> = 109) and non-Hispanic whites (<i>n</i> = 210) from the Microbiome and Insulin Longitudinal Evaluation Study. The ABO haplotype was determined by six SNPs located in the <i>ABO</i> gene. Based on prior knowledge, we included 21 gut bacteria and 13 plasma metabolites for mediation analysis. In the white study cohort (60 ± 9 years, 42% male), compared to the O1 haplotype, A1 was associated with a higher Matsuda insulin sensitivity index, while a lower relative abundance of <i>Bacteroides massiliensis</i> and lactate levels. Lactate was a likely mediator of this association but not <i>Bacteroides massiliensis</i>. In the AAs group (57 ± 8 years, 33% male), we found no association between any haplotype and insulin-related traits. In conclusion, the A1 haplotype may promote healthy insulin sensitivity in non-Hispanic whites and lactate likely play a role in this process but not selected gut bacteria. |
| first_indexed | 2024-03-09T23:12:12Z |
| format | Article |
| id | doaj.art-ddca9e3a9b9d42d2b7dc7d8fc4a1edaa |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T23:12:12Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-ddca9e3a9b9d42d2b7dc7d8fc4a1edaa2023-11-23T17:43:39ZengMDPI AGMetabolites2218-19892022-08-0112978710.3390/metabo12090787The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)Ruifang Li-Gao0Kirk Grubbs1Alain G. Bertoni2Kristi L. Hoffman3Joseph F. Petrosino4Gautam Ramesh5Martin Wu6Jerome I. Rotter7Yii-Der Ida Chen8Anne M. Evans9Richard J. Robinson10Laura Sommerville11Dennis Mook-Kanamori12Mark O. Goodarzi13Gregory A. Michelotti14Patricia A. Sheridan15Department of Clinical Epidemiology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsMetabolon, Inc., Morrisville, NC 27560, USADepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC 27101, USAAlkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USAAlkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USASchool of Medicine, University of California San Diego, La Jolla, CA 92161, USADepartment of Biology, University of Virginia, Charlottesville, VA 22904, USAThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USAThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USAMetabolon, Inc., Morrisville, NC 27560, USAMetabolon, Inc., Morrisville, NC 27560, USAMetabolon, Inc., Morrisville, NC 27560, USADepartment of Clinical Epidemiology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAMetabolon, Inc., Morrisville, NC 27560, USAMetabolon, Inc., Morrisville, NC 27560, USANon-O blood groups are associated with decreased insulin sensitivity and risk of type 2 diabetes. A recent study pinpointed the associations between ABO blood groups and gut microbiome, which may serve as potential mediators for the observed increased disease risks. We aimed to characterize associations between ABO haplotypes and insulin-related traits as well as potential mediating pathways. We assessed insulin homeostasis in African Americans (AAs; <i>n</i> = 109) and non-Hispanic whites (<i>n</i> = 210) from the Microbiome and Insulin Longitudinal Evaluation Study. The ABO haplotype was determined by six SNPs located in the <i>ABO</i> gene. Based on prior knowledge, we included 21 gut bacteria and 13 plasma metabolites for mediation analysis. In the white study cohort (60 ± 9 years, 42% male), compared to the O1 haplotype, A1 was associated with a higher Matsuda insulin sensitivity index, while a lower relative abundance of <i>Bacteroides massiliensis</i> and lactate levels. Lactate was a likely mediator of this association but not <i>Bacteroides massiliensis</i>. In the AAs group (57 ± 8 years, 33% male), we found no association between any haplotype and insulin-related traits. In conclusion, the A1 haplotype may promote healthy insulin sensitivity in non-Hispanic whites and lactate likely play a role in this process but not selected gut bacteria.https://www.mdpi.com/2218-1989/12/9/787insulin homeostasisABO blood typemetabolitesgut microbiomemediation analysis |
| spellingShingle | Ruifang Li-Gao Kirk Grubbs Alain G. Bertoni Kristi L. Hoffman Joseph F. Petrosino Gautam Ramesh Martin Wu Jerome I. Rotter Yii-Der Ida Chen Anne M. Evans Richard J. Robinson Laura Sommerville Dennis Mook-Kanamori Mark O. Goodarzi Gregory A. Michelotti Patricia A. Sheridan The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) Metabolites insulin homeostasis ABO blood type metabolites gut microbiome mediation analysis |
| title | The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
| title_full | The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
| title_fullStr | The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
| title_full_unstemmed | The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
| title_short | The Roles of Gut Microbiome and Plasma Metabolites in the Associations between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES) |
| title_sort | roles of gut microbiome and plasma metabolites in the associations between abo blood groups and insulin homeostasis the microbiome and insulin longitudinal evaluation study miles |
| topic | insulin homeostasis ABO blood type metabolites gut microbiome mediation analysis |
| url | https://www.mdpi.com/2218-1989/12/9/787 |
| work_keys_str_mv | AT ruifangligao therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT kirkgrubbs therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT alaingbertoni therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT kristilhoffman therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT josephfpetrosino therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT gautamramesh therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT martinwu therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT jeromeirotter therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT yiideridachen therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT annemevans therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT richardjrobinson therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT laurasommerville therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT dennismookkanamori therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT markogoodarzi therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT gregoryamichelotti therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT patriciaasheridan therolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT ruifangligao rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT kirkgrubbs rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT alaingbertoni rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT kristilhoffman rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT josephfpetrosino rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT gautamramesh rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT martinwu rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT jeromeirotter rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT yiideridachen rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT annemevans rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT richardjrobinson rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT laurasommerville rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT dennismookkanamori rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT markogoodarzi rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT gregoryamichelotti rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles AT patriciaasheridan rolesofgutmicrobiomeandplasmametabolitesintheassociationsbetweenabobloodgroupsandinsulinhomeostasisthemicrobiomeandinsulinlongitudinalevaluationstudymiles |