Pathogenicity of a TW-like strain of infectious bronchitis virus and evaluation of the protection induced against it by a QX-like strain
Avian infectious bronchitis (IB), a highly contagious disease caused by avian infectious bronchitis virus (IBV), is of considerable economic importance to the poultry industry. New IBV TW-like strains have increasingly emerged in China in recent years; hence, evaluating their pathogenicity and devel...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-10-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01653/full |
| _version_ | 1818844607221334016 |
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| author | Shi-hong Yan Yang Chen Jing Zhao Gang Xu Ye Zhao Guo-zhong Zhang |
| author_facet | Shi-hong Yan Yang Chen Jing Zhao Gang Xu Ye Zhao Guo-zhong Zhang |
| author_sort | Shi-hong Yan |
| collection | DOAJ |
| description | Avian infectious bronchitis (IB), a highly contagious disease caused by avian infectious bronchitis virus (IBV), is of considerable economic importance to the poultry industry. New IBV TW-like strains have increasingly emerged in China in recent years; hence, evaluating their pathogenicity and developing a specific vaccine to guard against their potential threat to the poultry industry is important. Here, we examined the pathogenicity of a TW-like IBV strain (GD), and evaluated the protective efficacy of the QX-like strain (JS) against GD in challenge infections in chickens. The results revealed that strain-GD-infected birds experienced severe respiratory signs, renal lesions, and 30%–40% mortality. The GD virus had extensive tissue tropism, especially in the trachea, lungs, kidneys, and bursa of Fabricius, and was continuously shed via the respiratory tract and cloaca. The QX-like IBV strain JS is able to completely protect chickens from challenge with the TW-like IBV GD field strain, with no clinical signs or gross lesions, decreased tissue replication rates, lower ciliostasis score and reduced virus shedding. These findings indicate that IBV GD is highly virulent, and that QX-like JS may serve as an effective vaccine against the threat posed by IBV TW-like viruses. |
| first_indexed | 2024-12-19T05:16:27Z |
| format | Article |
| id | doaj.art-ddcb814c15854274b9b73b3b5b22487c |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-19T05:16:27Z |
| publishDate | 2016-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-ddcb814c15854274b9b73b3b5b22487c2022-12-21T20:34:38ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-10-01710.3389/fmicb.2016.01653220721Pathogenicity of a TW-like strain of infectious bronchitis virus and evaluation of the protection induced against it by a QX-like strainShi-hong Yan0Yang Chen1Jing Zhao2Gang Xu3Ye Zhao4Guo-zhong Zhang5Key Laboratory of Animal Epidemiology and Zoonoses, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People’s Republic of ChinaKey Laboratory of Animal Epidemiology and Zoonoses, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People’s Republic of ChinaKey Laboratory of Animal Epidemiology and Zoonoses, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People’s Republic of ChinaKey Laboratory of Animal Epidemiology and Zoonoses, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People’s Republic of ChinaKey Laboratory of Animal Epidemiology and Zoonoses, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People’s Republic of ChinaKey Laboratory of Animal Epidemiology and Zoonoses, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People’s Republic of ChinaAvian infectious bronchitis (IB), a highly contagious disease caused by avian infectious bronchitis virus (IBV), is of considerable economic importance to the poultry industry. New IBV TW-like strains have increasingly emerged in China in recent years; hence, evaluating their pathogenicity and developing a specific vaccine to guard against their potential threat to the poultry industry is important. Here, we examined the pathogenicity of a TW-like IBV strain (GD), and evaluated the protective efficacy of the QX-like strain (JS) against GD in challenge infections in chickens. The results revealed that strain-GD-infected birds experienced severe respiratory signs, renal lesions, and 30%–40% mortality. The GD virus had extensive tissue tropism, especially in the trachea, lungs, kidneys, and bursa of Fabricius, and was continuously shed via the respiratory tract and cloaca. The QX-like IBV strain JS is able to completely protect chickens from challenge with the TW-like IBV GD field strain, with no clinical signs or gross lesions, decreased tissue replication rates, lower ciliostasis score and reduced virus shedding. These findings indicate that IBV GD is highly virulent, and that QX-like JS may serve as an effective vaccine against the threat posed by IBV TW-like viruses.http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01653/fullVaccinepathogenicityefficacyIsolateAvian infectious bronchitis virus |
| spellingShingle | Shi-hong Yan Yang Chen Jing Zhao Gang Xu Ye Zhao Guo-zhong Zhang Pathogenicity of a TW-like strain of infectious bronchitis virus and evaluation of the protection induced against it by a QX-like strain Frontiers in Microbiology Vaccine pathogenicity efficacy Isolate Avian infectious bronchitis virus |
| title | Pathogenicity of a TW-like strain of infectious bronchitis virus and evaluation of the protection induced against it by a QX-like strain |
| title_full | Pathogenicity of a TW-like strain of infectious bronchitis virus and evaluation of the protection induced against it by a QX-like strain |
| title_fullStr | Pathogenicity of a TW-like strain of infectious bronchitis virus and evaluation of the protection induced against it by a QX-like strain |
| title_full_unstemmed | Pathogenicity of a TW-like strain of infectious bronchitis virus and evaluation of the protection induced against it by a QX-like strain |
| title_short | Pathogenicity of a TW-like strain of infectious bronchitis virus and evaluation of the protection induced against it by a QX-like strain |
| title_sort | pathogenicity of a tw like strain of infectious bronchitis virus and evaluation of the protection induced against it by a qx like strain |
| topic | Vaccine pathogenicity efficacy Isolate Avian infectious bronchitis virus |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01653/full |
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