An evaluation of TAZ and YAP crosstalk with TGFβ signalling in canine osteosarcoma suggests involvement of hippo signalling in disease progression

An evaluation of TAZ and YAP crosstalk with TGFβ signalling in canine osteosarcoma suggests involvement of hippo signalling in disease progression

Abstract Background Osteosarcoma (OSA) is the most common bone cancer in canines. Both transforming growth factor beta (TGFβ) and Hippo pathway mediators have important roles in bone development, stemness, and cancer progression. The role of Hippo signalling effectors TAZ and YAP has never been addr...

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Bibliographic Details
Main Authors: Anita K. Luu, Courtney R. Schott, Robert Jones, Andrew C. Poon, Brandon Golding, Roa’a Hamed, Benjamin Deheshi, Anthony Mutsaers, Geoffrey A. Wood, Alicia M. Viloria-Petit
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Veterinary Research
Subjects:
Canine osteosarcoma
Hippo signalling
TGFβ
YAP1
TAZ
WWTR1
Online Access:http://link.springer.com/article/10.1186/s12917-018-1651-5

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