Identification of new type I interferon-stimulated genes and investigation of their involvement in IFN-β activation

Identification of new type I interferon-stimulated genes and investigation of their involvement in IFN-β activation

Abstract Virus infection induces the production of type I interferons (IFNs). IFNs bind to their heterodimeric receptors to initiate downstream cascade of signaling, leading to the up-regulation of interferon-stimulated genes (ISGs). ISGs play very important roles in innate immunity through a variet...

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Bibliographic Details
Main Authors: Xiaolin Zhang, Wei Yang, Xinlu Wang, Xuyuan Zhang, Huabin Tian, Hongyu Deng, Liguo Zhang, Guangxia Gao
Format: Article
Language:English
Published: Oxford University Press 2018-02-01
Series:Protein & Cell
Subjects:
interferon-stimulated genes
IFN-β signaling
PIM1
RIG-I
MDA5
Online Access:http://link.springer.com/article/10.1007/s13238-018-0511-1

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