Adaptation of Bacteria to Antineoplastic Agents Involves Persister Cells and Increases Resistance to Antibiotics
The increasing number of life-threatening infections observed in cancer patients has been ascribed to chemotherapy-induced neutropenia and to invasive medical procedures such as surgery and the application of catheters. In this study, it was questioned if the infections could also be favored by an i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/9/8/355 |
| _version_ | 1797439506117296128 |
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| author | Carla C. C. R. de Carvalho |
| author_facet | Carla C. C. R. de Carvalho |
| author_sort | Carla C. C. R. de Carvalho |
| collection | DOAJ |
| description | The increasing number of life-threatening infections observed in cancer patients has been ascribed to chemotherapy-induced neutropenia and to invasive medical procedures such as surgery and the application of catheters. In this study, it was questioned if the infections could also be favored by an increased resistance of bacteria due to the adaptation to antineoplastic agents used in chemotherapy. After exposure to several antineoplastic agents, it was observed that cells of <i>Staphylococcus aureus</i>, <i>Mycobacterium vaccae</i>, <i>Pseudomonas aeruginosa,</i> and <i>Escherichia coli</i> changed the fatty acid profile of their cellular membranes, produced exopolymeric substances, and formed aggregates that adhered to surfaces. Additionally, when exposed to high concentrations of these compounds, a persister sub-population could be identified. After adaptation to antineoplastic agents, the minimum inhibitory concentration (MIC) of several antibiotics increased considerably in the tested strains. |
| first_indexed | 2024-03-09T11:53:44Z |
| format | Article |
| id | doaj.art-ddccfd6065ea415c9130634d16ebdfcc |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-09T11:53:44Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-ddccfd6065ea415c9130634d16ebdfcc2023-11-30T23:12:10ZengMDPI AGBioengineering2306-53542022-07-019835510.3390/bioengineering9080355Adaptation of Bacteria to Antineoplastic Agents Involves Persister Cells and Increases Resistance to AntibioticsCarla C. C. R. de Carvalho0iBB-Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, PortugalThe increasing number of life-threatening infections observed in cancer patients has been ascribed to chemotherapy-induced neutropenia and to invasive medical procedures such as surgery and the application of catheters. In this study, it was questioned if the infections could also be favored by an increased resistance of bacteria due to the adaptation to antineoplastic agents used in chemotherapy. After exposure to several antineoplastic agents, it was observed that cells of <i>Staphylococcus aureus</i>, <i>Mycobacterium vaccae</i>, <i>Pseudomonas aeruginosa,</i> and <i>Escherichia coli</i> changed the fatty acid profile of their cellular membranes, produced exopolymeric substances, and formed aggregates that adhered to surfaces. Additionally, when exposed to high concentrations of these compounds, a persister sub-population could be identified. After adaptation to antineoplastic agents, the minimum inhibitory concentration (MIC) of several antibiotics increased considerably in the tested strains.https://www.mdpi.com/2306-5354/9/8/355mitomycin Ccyclophosphamideetoposidemethotrexatecancertolerance |
| spellingShingle | Carla C. C. R. de Carvalho Adaptation of Bacteria to Antineoplastic Agents Involves Persister Cells and Increases Resistance to Antibiotics Bioengineering mitomycin C cyclophosphamide etoposide methotrexate cancer tolerance |
| title | Adaptation of Bacteria to Antineoplastic Agents Involves Persister Cells and Increases Resistance to Antibiotics |
| title_full | Adaptation of Bacteria to Antineoplastic Agents Involves Persister Cells and Increases Resistance to Antibiotics |
| title_fullStr | Adaptation of Bacteria to Antineoplastic Agents Involves Persister Cells and Increases Resistance to Antibiotics |
| title_full_unstemmed | Adaptation of Bacteria to Antineoplastic Agents Involves Persister Cells and Increases Resistance to Antibiotics |
| title_short | Adaptation of Bacteria to Antineoplastic Agents Involves Persister Cells and Increases Resistance to Antibiotics |
| title_sort | adaptation of bacteria to antineoplastic agents involves persister cells and increases resistance to antibiotics |
| topic | mitomycin C cyclophosphamide etoposide methotrexate cancer tolerance |
| url | https://www.mdpi.com/2306-5354/9/8/355 |
| work_keys_str_mv | AT carlaccrdecarvalho adaptationofbacteriatoantineoplasticagentsinvolvespersistercellsandincreasesresistancetoantibiotics |