DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis

DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis

Abstract Background Multiple factors, including interactions between genetic and environmental risks, are important in susceptibility to rheumatoid arthritis (RA). However, the underlying mechanism is not fully understood. This study was undertaken to evaluate whether DNA methylation can mediate the...

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Bibliographic Details
Main Authors: Weida Meng, Zaihua Zhu, Xia Jiang, Chun Lai Too, Steffen Uebe, Maja Jagodic, Ingrid Kockum, Shahnaz Murad, Luigi Ferrucci, Lars Alfredsson, Hejian Zou, Lars Klareskog, Andrew P. Feinberg, Tomas J. Ekström, Leonid Padyukov, Yun Liu
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Smoking
Epidemiology
Online Access:http://link.springer.com/article/10.1186/s13075-017-1276-2

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