Hypoxia related long non-coding RNAs in ischemic stroke
With high rates of mortality and disability, stroke has caused huge social burden, and 85% of which is ischemic stroke. In recent years, it is a progressive discovery of long non-coding RNA (lncRNA) playing an important regulatory role throughout ischemic stroke. Hypoxia, generated from reduction or...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2021-12-01
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| Series: | Non-coding RNA Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054021000391 |
| _version_ | 1797205104785358848 |
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| author | Jiawei Yao Yiming Du Junsi Liu Ilgiz Gareev Guang Yang Xiaohui Kang Xiaoxiong Wang Ozal Beylerli Xin Chen |
| author_facet | Jiawei Yao Yiming Du Junsi Liu Ilgiz Gareev Guang Yang Xiaohui Kang Xiaoxiong Wang Ozal Beylerli Xin Chen |
| author_sort | Jiawei Yao |
| collection | DOAJ |
| description | With high rates of mortality and disability, stroke has caused huge social burden, and 85% of which is ischemic stroke. In recent years, it is a progressive discovery of long non-coding RNA (lncRNA) playing an important regulatory role throughout ischemic stroke. Hypoxia, generated from reduction or interruption of cerebral blood flow, leads to changes in lncRNA expression, which then influence disease progression. Therefore, we reviewed studies on expression of hypoxia-related lncRNAs and relevant molecular mechanism in ischemic stroke. Considering that hypoxia-inducible factor (HIF) is a crucial regulator in hypoxic progress, we mainly focus on the HIF-related lncRNA which regulates the expression of HIF or is regulated by HIF, further reveal their pathogenesis and adaption after brain ischemia and hypoxia, so as to find effective biomarker and therapeutic targets. |
| first_indexed | 2024-04-24T08:45:49Z |
| format | Article |
| id | doaj.art-ddcf5e52357e43f78201ae614897e9eb |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-24T08:45:49Z |
| publishDate | 2021-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-ddcf5e52357e43f78201ae614897e9eb2024-04-16T13:36:50ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402021-12-0164153158Hypoxia related long non-coding RNAs in ischemic strokeJiawei Yao0Yiming Du1Junsi Liu2Ilgiz Gareev3Guang Yang4Xiaohui Kang5Xiaoxiong Wang6Ozal Beylerli7Xin Chen8Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, ChinaDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, ChinaDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, ChinaBashkir State Medical University, Ufa, Republic of Bashkortostan, 450008, RussiaDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, ChinaDepartment of Pharmacy, Rizhao People's Hospital, Rizhao, 276826, Shandong Province, ChinaDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Corresponding author. Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.Bashkir State Medical University, Ufa, Republic of Bashkortostan, 450008, Russia; Corresponding author.Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Institute of Neuroscience, Sino-Russian Medical Research Center, Harbin Medical University, Harbin, 150001, Heilongjiang Province, China; Corresponding author. Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.With high rates of mortality and disability, stroke has caused huge social burden, and 85% of which is ischemic stroke. In recent years, it is a progressive discovery of long non-coding RNA (lncRNA) playing an important regulatory role throughout ischemic stroke. Hypoxia, generated from reduction or interruption of cerebral blood flow, leads to changes in lncRNA expression, which then influence disease progression. Therefore, we reviewed studies on expression of hypoxia-related lncRNAs and relevant molecular mechanism in ischemic stroke. Considering that hypoxia-inducible factor (HIF) is a crucial regulator in hypoxic progress, we mainly focus on the HIF-related lncRNA which regulates the expression of HIF or is regulated by HIF, further reveal their pathogenesis and adaption after brain ischemia and hypoxia, so as to find effective biomarker and therapeutic targets.http://www.sciencedirect.com/science/article/pii/S2468054021000391Long non coding RNAIschemic strokeHypoxiaHIF |
| spellingShingle | Jiawei Yao Yiming Du Junsi Liu Ilgiz Gareev Guang Yang Xiaohui Kang Xiaoxiong Wang Ozal Beylerli Xin Chen Hypoxia related long non-coding RNAs in ischemic stroke Non-coding RNA Research Long non coding RNA Ischemic stroke Hypoxia HIF |
| title | Hypoxia related long non-coding RNAs in ischemic stroke |
| title_full | Hypoxia related long non-coding RNAs in ischemic stroke |
| title_fullStr | Hypoxia related long non-coding RNAs in ischemic stroke |
| title_full_unstemmed | Hypoxia related long non-coding RNAs in ischemic stroke |
| title_short | Hypoxia related long non-coding RNAs in ischemic stroke |
| title_sort | hypoxia related long non coding rnas in ischemic stroke |
| topic | Long non coding RNA Ischemic stroke Hypoxia HIF |
| url | http://www.sciencedirect.com/science/article/pii/S2468054021000391 |
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