Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn’s Disease: Results from the IMPACT Study
Limited studies have examined the intestinal microbiota composition in relation to Crohn’s disease (CD) prognosis. We analyzed the differences in microbial communities and relevant metabolic pathways associated with prognostic variables in patients with CD. We applied 16S rRNA gene sequencing to ana...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/6/1748 |
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| author | Soo-kyung Park Han-Na Kim Chang Hwan Choi Jong Pil Im Jae Myung Cha Chang Soo Eun Tae-Oh Kim Sang-Bum Kang Ki Bae Bang Hyun Gun Kim Yunho Jung Hyuk Yoon Dong-Soo Han Chil-Woo Lee Kwangsung Ahn Hyung-Lae Kim Dong Il Park |
| author_facet | Soo-kyung Park Han-Na Kim Chang Hwan Choi Jong Pil Im Jae Myung Cha Chang Soo Eun Tae-Oh Kim Sang-Bum Kang Ki Bae Bang Hyun Gun Kim Yunho Jung Hyuk Yoon Dong-Soo Han Chil-Woo Lee Kwangsung Ahn Hyung-Lae Kim Dong Il Park |
| author_sort | Soo-kyung Park |
| collection | DOAJ |
| description | Limited studies have examined the intestinal microbiota composition in relation to Crohn’s disease (CD) prognosis. We analyzed the differences in microbial communities and relevant metabolic pathways associated with prognostic variables in patients with CD. We applied 16S rRNA gene sequencing to analyze a cohort of 1110 CD and healthy control (HC) fecal samples. We categorized patients with CD into good (CD-G), intermediate (CD-I) and poor (CD-P) prognosis groups, according to the history of using biologics and intestinal resection. Microbiota α-diversity decreased more in CD-P than CD-G and CD-I. Microbiota ß-diversity in CD-P differed from that in CD-G and CD-I. Thirteen genera and 10 species showed differential abundance between CD-G and CD-P groups. <i>Escherichia coli</i> (<i>p</i> = 0.001) and species <i>Producta</i> (<i>p</i> = 0.01) and genera <i>Lactobacillus</i> (<i>p</i> = 0.003) and Coprococcus (<i>p</i> = 0.01) consistently showed differences between CD-G and CD-P groups after adjusting for confounding variables. Functional profiling suggested that the microbial catabolic pathways and pathways related to enterobacterial common antigen and lipopolysaccharide biosynthesis were better represented in the CD-P group than in the CD-G group, and <i>E. coli</i> were the top contributors to these pathways. CD prognosis is associated with altered microbiota composition and decreased diversity, and <i>E. coli</i> might be causally involved in CD progression, and may have adapted to live in inflammatory environments. |
| first_indexed | 2024-03-10T19:22:14Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T19:22:14Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-ddcfc96f72154c5da88609db7ba733332023-11-20T02:55:42ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0196174810.3390/jcm9061748Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn’s Disease: Results from the IMPACT StudySoo-kyung Park0Han-Na Kim1Chang Hwan Choi2Jong Pil Im3Jae Myung Cha4Chang Soo Eun5Tae-Oh Kim6Sang-Bum Kang7Ki Bae Bang8Hyun Gun Kim9Yunho Jung10Hyuk Yoon11Dong-Soo Han12Chil-Woo Lee13Kwangsung Ahn14Hyung-Lae Kim15Dong Il Park16Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, KoreaMedical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, KoreaInflammatory Bowel Disease Study Group of the Korean Association for the Study of Intestinal Diseases, Seoul 06193, KoreaInflammatory Bowel Disease Study Group of the Korean Association for the Study of Intestinal Diseases, Seoul 06193, KoreaDepartment of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul 02447, KoreaDepartment of Internal Medicine, Hanyang University Guri Hospital, Guri 11923, KoreaInflammatory Bowel Disease Study Group of the Korean Association for the Study of Intestinal Diseases, Seoul 06193, KoreaDivision of Gastroenterology, Department of Internal medicine, Daejeon St. Mary’s Hospital, The Catholic University of Korea, Daejeon 34943, KoreaDepartment of Internal Medicine, Dankook University College of Medicine, Cheonan 31116, KoreaDivision of Gastroenterology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul Hospital, Seoul 04401, KoreaDivision of Gastroenterology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan 31151, KoreaInflammatory Bowel Disease Study Group of the Korean Association for the Study of Intestinal Diseases, Seoul 06193, KoreaDepartment of Internal Medicine, Hanyang University Guri Hospital, Guri 11923, KoreaMedical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, KoreaFunctional Genome Institute, PDXen Biosystems Inc., Daejeon 34129, KoreaDepartment of Biochemistry, School of Medicine, Ewha Womans University, Seoul 07804, KoreaDivision of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, KoreaLimited studies have examined the intestinal microbiota composition in relation to Crohn’s disease (CD) prognosis. We analyzed the differences in microbial communities and relevant metabolic pathways associated with prognostic variables in patients with CD. We applied 16S rRNA gene sequencing to analyze a cohort of 1110 CD and healthy control (HC) fecal samples. We categorized patients with CD into good (CD-G), intermediate (CD-I) and poor (CD-P) prognosis groups, according to the history of using biologics and intestinal resection. Microbiota α-diversity decreased more in CD-P than CD-G and CD-I. Microbiota ß-diversity in CD-P differed from that in CD-G and CD-I. Thirteen genera and 10 species showed differential abundance between CD-G and CD-P groups. <i>Escherichia coli</i> (<i>p</i> = 0.001) and species <i>Producta</i> (<i>p</i> = 0.01) and genera <i>Lactobacillus</i> (<i>p</i> = 0.003) and Coprococcus (<i>p</i> = 0.01) consistently showed differences between CD-G and CD-P groups after adjusting for confounding variables. Functional profiling suggested that the microbial catabolic pathways and pathways related to enterobacterial common antigen and lipopolysaccharide biosynthesis were better represented in the CD-P group than in the CD-G group, and <i>E. coli</i> were the top contributors to these pathways. CD prognosis is associated with altered microbiota composition and decreased diversity, and <i>E. coli</i> might be causally involved in CD progression, and may have adapted to live in inflammatory environments.https://www.mdpi.com/2077-0383/9/6/1748Crohn’s diseaseprognosismicrobiota |
| spellingShingle | Soo-kyung Park Han-Na Kim Chang Hwan Choi Jong Pil Im Jae Myung Cha Chang Soo Eun Tae-Oh Kim Sang-Bum Kang Ki Bae Bang Hyun Gun Kim Yunho Jung Hyuk Yoon Dong-Soo Han Chil-Woo Lee Kwangsung Ahn Hyung-Lae Kim Dong Il Park Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn’s Disease: Results from the IMPACT Study Journal of Clinical Medicine Crohn’s disease prognosis microbiota |
| title | Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn’s Disease: Results from the IMPACT Study |
| title_full | Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn’s Disease: Results from the IMPACT Study |
| title_fullStr | Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn’s Disease: Results from the IMPACT Study |
| title_full_unstemmed | Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn’s Disease: Results from the IMPACT Study |
| title_short | Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn’s Disease: Results from the IMPACT Study |
| title_sort | differentially abundant bacterial taxa associated with prognostic variables of crohn s disease results from the impact study |
| topic | Crohn’s disease prognosis microbiota |
| url | https://www.mdpi.com/2077-0383/9/6/1748 |
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