Connection of Cancer Exosomal LncRNAs, Sponging miRNAs, and Exosomal Processing and Their Potential Modulation by Natural Products
Cancerous exosomes contain diverse biomolecules that regulate cancer progression. Modulating exosome biogenesis with clinical drugs has become an effective strategy for cancer therapy. Suppressing exosomal processing (assembly and secretion) may block exosomal function to reduce the proliferation of...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/8/2215 |
| _version_ | 1797606100016562176 |
|---|---|
| author | Ya-Ting Chuang Jun-Ping Shiau Jen-Yang Tang Ammad Ahmad Farooqi Fang-Rong Chang Yi-Hong Tsai Ching-Yu Yen Hsueh-Wei Chang |
| author_facet | Ya-Ting Chuang Jun-Ping Shiau Jen-Yang Tang Ammad Ahmad Farooqi Fang-Rong Chang Yi-Hong Tsai Ching-Yu Yen Hsueh-Wei Chang |
| author_sort | Ya-Ting Chuang |
| collection | DOAJ |
| description | Cancerous exosomes contain diverse biomolecules that regulate cancer progression. Modulating exosome biogenesis with clinical drugs has become an effective strategy for cancer therapy. Suppressing exosomal processing (assembly and secretion) may block exosomal function to reduce the proliferation of cancer cells. However, the information on natural products that modulate cancer exosomes lacks systemic organization, particularly for exosomal long noncoding RNAs (lncRNAs). There is a gap in the connection between exosomal lncRNAs and exosomal processing. This review introduces the database (LncTarD) to explore the potential of exosomal lncRNAs and their sponging miRNAs. The names of sponging miRNAs were transferred to the database (miRDB) for the target prediction of exosomal processing genes. Moreover, the impacts of lncRNAs, sponging miRNAs, and exosomal processing on the tumor microenvironment (TME) and natural-product-modulating anticancer effects were then retrieved and organized. This review sheds light on the functions of exosomal lncRNAs, sponging miRNAs, and exosomal processing in anticancer processes. It also provides future directions for the application of natural products when regulating cancerous exosomal lncRNAs. |
| first_indexed | 2024-03-11T05:10:31Z |
| format | Article |
| id | doaj.art-ddcfdfbd6bae4638aca9d0e35107a99b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T05:10:31Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ddcfdfbd6bae4638aca9d0e35107a99b2023-11-17T18:37:55ZengMDPI AGCancers2072-66942023-04-01158221510.3390/cancers15082215Connection of Cancer Exosomal LncRNAs, Sponging miRNAs, and Exosomal Processing and Their Potential Modulation by Natural ProductsYa-Ting Chuang0Jun-Ping Shiau1Jen-Yang Tang2Ammad Ahmad Farooqi3Fang-Rong Chang4Yi-Hong Tsai5Ching-Yu Yen6Hsueh-Wei Chang7Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDivision of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, TaiwanSchool of Post-Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 80708, TaiwanInstitute of Biomedical and Genetic Engineering (IBGE), Islamabad 54000, PakistanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, TaiwanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, TaiwanSchool of Dentistry, Taipei Medical University, Taipei 11031, TaiwanGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, TaiwanCancerous exosomes contain diverse biomolecules that regulate cancer progression. Modulating exosome biogenesis with clinical drugs has become an effective strategy for cancer therapy. Suppressing exosomal processing (assembly and secretion) may block exosomal function to reduce the proliferation of cancer cells. However, the information on natural products that modulate cancer exosomes lacks systemic organization, particularly for exosomal long noncoding RNAs (lncRNAs). There is a gap in the connection between exosomal lncRNAs and exosomal processing. This review introduces the database (LncTarD) to explore the potential of exosomal lncRNAs and their sponging miRNAs. The names of sponging miRNAs were transferred to the database (miRDB) for the target prediction of exosomal processing genes. Moreover, the impacts of lncRNAs, sponging miRNAs, and exosomal processing on the tumor microenvironment (TME) and natural-product-modulating anticancer effects were then retrieved and organized. This review sheds light on the functions of exosomal lncRNAs, sponging miRNAs, and exosomal processing in anticancer processes. It also provides future directions for the application of natural products when regulating cancerous exosomal lncRNAs.https://www.mdpi.com/2072-6694/15/8/2215exosomeanticancerlncRNAssponging miRNAsexosomal processingnatural product |
| spellingShingle | Ya-Ting Chuang Jun-Ping Shiau Jen-Yang Tang Ammad Ahmad Farooqi Fang-Rong Chang Yi-Hong Tsai Ching-Yu Yen Hsueh-Wei Chang Connection of Cancer Exosomal LncRNAs, Sponging miRNAs, and Exosomal Processing and Their Potential Modulation by Natural Products Cancers exosome anticancer lncRNAs sponging miRNAs exosomal processing natural product |
| title | Connection of Cancer Exosomal LncRNAs, Sponging miRNAs, and Exosomal Processing and Their Potential Modulation by Natural Products |
| title_full | Connection of Cancer Exosomal LncRNAs, Sponging miRNAs, and Exosomal Processing and Their Potential Modulation by Natural Products |
| title_fullStr | Connection of Cancer Exosomal LncRNAs, Sponging miRNAs, and Exosomal Processing and Their Potential Modulation by Natural Products |
| title_full_unstemmed | Connection of Cancer Exosomal LncRNAs, Sponging miRNAs, and Exosomal Processing and Their Potential Modulation by Natural Products |
| title_short | Connection of Cancer Exosomal LncRNAs, Sponging miRNAs, and Exosomal Processing and Their Potential Modulation by Natural Products |
| title_sort | connection of cancer exosomal lncrnas sponging mirnas and exosomal processing and their potential modulation by natural products |
| topic | exosome anticancer lncRNAs sponging miRNAs exosomal processing natural product |
| url | https://www.mdpi.com/2072-6694/15/8/2215 |
| work_keys_str_mv | AT yatingchuang connectionofcancerexosomallncrnasspongingmirnasandexosomalprocessingandtheirpotentialmodulationbynaturalproducts AT junpingshiau connectionofcancerexosomallncrnasspongingmirnasandexosomalprocessingandtheirpotentialmodulationbynaturalproducts AT jenyangtang connectionofcancerexosomallncrnasspongingmirnasandexosomalprocessingandtheirpotentialmodulationbynaturalproducts AT ammadahmadfarooqi connectionofcancerexosomallncrnasspongingmirnasandexosomalprocessingandtheirpotentialmodulationbynaturalproducts AT fangrongchang connectionofcancerexosomallncrnasspongingmirnasandexosomalprocessingandtheirpotentialmodulationbynaturalproducts AT yihongtsai connectionofcancerexosomallncrnasspongingmirnasandexosomalprocessingandtheirpotentialmodulationbynaturalproducts AT chingyuyen connectionofcancerexosomallncrnasspongingmirnasandexosomalprocessingandtheirpotentialmodulationbynaturalproducts AT hsuehweichang connectionofcancerexosomallncrnasspongingmirnasandexosomalprocessingandtheirpotentialmodulationbynaturalproducts |